Evidence map›Paper›PMID 39663002›Full record

ArticleThe British journal of ophthalmology2025

Number of macula optical coherence tomography scans needed to detect glaucoma progression.

Golnoush Mahmoudinezhad, Sasan Moghimi, Kareem Latif, Nicole Brye, Evan Walker, Takashi Nishida, Kelvin H Du, Gopikasree Gunasegaran, Jo-Hsuan Wu, Jeffrey M Liebmann and 4 more

2 registry-linked trialsAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00221897 recruitingnot on this map

Diagnostic Innovations in Glaucoma Study

TypeobservationalSponsorUniversity of California, San DiegoRan1995 to 2030Enrolled3,000ConditionsPrimary Open Angle Glaucoma, Myopia
NCT00221923 unknown statusnot on this map

African Descent and Glaucoma Evaluation Study (Formerly African Americans With Glaucoma Study)

TypeobservationalSponsorUniversity of California, San DiegoRan2002 to 2022Enrolled1,540ConditionsPrimary Open Angle Glaucoma
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Telemedicine in ophthalmology.Wiener medizinische Wochenschrift (1946) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Golnoush Mahmoudinezhad *Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Sasan Moghimi *Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0002-9375-4711
Kareem LatifViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Nicole BryeViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Evan WalkerViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0001-8566-0371
Takashi NishidaViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0002-8312-6623
Kelvin H DuViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Gopikasree GunasegaranViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Jo-Hsuan WuViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0002-9435-746X
Jeffrey M LiebmannBernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York, USA.
Massimo A FazioOphthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID http://orcid.org/0000-0002-7489-089X
Christopher A GirkinBernard School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Linda M ZangwillViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0002-1143-5224
Robert N WeinrebViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA rweinreb@ucsd.edu.ORCID http://orcid.org/0000-0001-9553-3202

Funding

African Descent And Glaucoma Evaluation Study (ADAGES)U10EY014267 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2002 to 2010
$13.2M
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
Age-related changes in optic nerve head structure and biomechanicsR01EY018926 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DOWNS, J CRAWFORD, GIRKIN, CHRISTOPHER ANTHONY · 2008 to 2015
$2.6M
African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progressionR01EY026574 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2017 to 2020
$2.6M
Monitoring of Glaucoma Patients in Advanced DiseaseR01EY034148 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sasan Moghimi Araghi · 2022 to 2026
$2.5M
Multimodal Artificial Intelligence to Predict Glaucomatous Progression and Surgical InterventionR01EY034146 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAXTER, SALLY LIU, CHRISTOPHER, MARK · 2022 to 2025
$1.8M
Determinants of the Biomechanical Behavior of the Human Lamina CribrosaR01EY028284 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2018 to 2021
$1.5M
OCT in the Ocular Hypertension Treatment Study: 20 Year Follow-upR21EY031125 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2020 to 2021
$442k
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY018926NEI NIH HHS R01 EY026574NEI NIH HHS R01 EY027510NEI NIH HHS R01 EY028284NEI NIH HHS R01 EY029058NEI NIH HHS R01 EY034146NEI NIH HHS R01 EY034148NEI NIH HHS R21 EY031125NEI NIH HHS U10 EY014267
6 · The paper itself

Abstract

backgroundTo evaluate the impact of testing frequency on the time required to detect statistically significant glaucoma progression for ganglion cell complex (GCC) with optical coherence tomography (OCT). MATERIALS AND

methodsFrom multicentre glaucoma registries, 332 eyes of 201 glaucoma patients were enrolled over an average of 4.4 years. Patients with 4 or more OCT tests were selected to calculate the longitudinal rates of GCC thickness change over time by linear regression. A computer simulation was then used to generate real-world GCC data and assess the time required to detect progression at different loss rates and testing frequencies based on variability estimates. Time and accuracy to detect worsening of progression were calculated.

resultsAs testing frequency increased, the time required to detect a statistically significant negative GCC slope decreased, but not proportionally. All eyes with a GCC loss of -1 µm/year progressed after 3.8, 2.6 and 2.2 years on average when testing was conducted one, two and three times per year, respectively. For eyes with a GCC loss of -1.5 µm/year, progression was identified after 3.3, 2.2, and 1.8 years on average, respectively.

conclusionIncreasing the frequency of macular OCT testing to three times per year more sensitively detects progression compared with two times per year. However, two times per year testing may be sufficient in clinical settings to detect progression and also to reduce the healthcare burden. TRIAL REGISTRATION NUMBERS: NCT00221897, NCT00221923.

Indexed as

GlaucomaMacula LuteaRetinal Ganglion CellsTomography, Optical CoherenceAgedDisease ProgressionFemaleFollow-Up StudiesHumansIntraocular PressureMaleMiddle AgedNerve FibersRegistriesVisual FieldsGlaucomaMacula

Identifiers

PMID39663002
PMCPMC12124970

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.