Evidence map›Paper›PMID 39662950›Full record

ArticleCirculation journal : official journal of the Japanese Circulation Society2025

Association of Blood Urea Nitrogen With Incident Heart Failure in the Community　- The Atherosclerosis Risk in Communities (ARIC) Study.

Hairong Liu, Junichi Ishigami, Lena Mathews, Suma Konety, Michael Hall, Patricia P Chang, Chiadi Ndumele, Wayne Rosamond, Kunihiro Matsushita

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation journal : official journal of the Japanese Circulation Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hairong LiuDepartment of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health.
Junichi IshigamiDepartment of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health.
Lena MathewsDepartment of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health.
Suma KonetyDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota.
Michael HallDepartment of Medicine, University of Mississippi Medical Center.
Patricia P ChangDepartment of Epidemiology, Grillings School of Global Public Health, University of North Carolina at Chapel Hill.
Chiadi NdumeleDepartment of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health.
Wayne RosamondDepartment of Epidemiology, Grillings School of Global Public Health, University of North Carolina at Chapel Hill.
Kunihiro MatsushitaDepartment of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health.

Funding

NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS L30 HL154407
6 · The paper itself

Abstract

backgroundThe association between blood urea nitrogen (BUN) levels and incident heart failure (HF) in the general population is still unclear. METHODS AND

resultsWe assessed the association of BUN level with incident HF in 14,167 ARIC participants without a history of HF at baseline (1987-1989) (mean age 54.1 years, 54.4% female, 25.2% Black). BUN levels (mg/dL) were divided into quartiles, with the highest quartile further divided into tertiles (Q1 ≤13, Q2 13-15, Q3 15-17, Q4a 17-19, Q4b 19-21, Q4c >21). HF events were identified through to December 31, 2019, using diagnostic codes on discharge records or death certificates. Hazard ratios (HRs) were estimated using multivariable Cox models. During a median follow-up of 26.2 years, 3,482 participants developed HF (incidence rate 10.7 per 1,000 person-years). In a multivariable Cox model adjusted for sociodemographic variables, the highest BUN quartile (Q4) had a HR of 1.19 (95% confidence interval [CI] 1.09, 1.31) compared with Q1. HRs for Q4a, Q4b, and Q4c were 1.14 (95% CI 1.02, 1.28), 1.11 (0.96, 1.28), and 1.42 (1.22, 1.63), respectively. After further adjustment for clinical factors, the association remained significant for Q4c (HR 1.23 [1.06, 1.43]). Associations were consistent across demographic and clinical subgroups.

conclusionsIn this community-based cohort, higher BUN levels were significantly associated with incident HF. BUN, routinely measured in clinical care, may help identify individuals at risk of HF.

Indexed as

AtherosclerosisBlood Urea NitrogenHeart FailureAgedBiomarkersFemaleHumansIncidenceMaleMiddle AgedProspective StudiesRisk AssessmentRisk FactorsUnited StatesBiomarkersCardiac diseaseCardiac markersClinical decision supportHeart failure

Identifiers

PMID39662950
PMCPMC12854080

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