Evidence map›Paper›PMID 39662912›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Anti-Tr/DNER Antibody-associated Paraneoplastic Neurological Syndrome Presenting Limbic Encephalitis with Anaplastic Large Cell Lymphoma.

Shintaro Fujii, Hiroaki Yaguchi, Ikuko Takahashi-Iwata, Takashi Inoue, Monami Tarisawa, Taichi Nomura, Akihiko Kudo, Hisashi Uwatoko, Shinichi Shirai, Masaaki Matsushima and 7 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shintaro FujiiDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Hiroaki YaguchiDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Ikuko Takahashi-IwataDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Takashi InoueDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Monami TarisawaDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Taichi NomuraDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Akihiko KudoDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Hisashi UwatokoDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Shinichi ShiraiDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Masaaki MatsushimaDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Riku MiyaishiDepartment of Surgical Pathology, Hokkaido University Hospital, Japan.
Noriyuki OtsukaDepartment of Surgical Pathology, Hokkaido University Hospital, Japan.
Keiko TanakaDepartment of Animal Model Development, Brain Research Institute, Niigata University, Japan.
Koji TaniguchiDepartment of Pathology, Faculty of Medicine, Hokkaido University, Japan.
Masato TakahashiDepartment of Breast Surgery, Hokkaido University Hospital, Japan.
Shinya TanakaDepartment of Surgical Pathology, Hokkaido University Hospital, Japan.
Ichiro YabeDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 82-year-old man presented with acute progressive disturbance of consciousness. We suspected autoimmune limbic encephalitis because of abnormal magnetic resonance imaging findings in the bilateral temporal lobes and cerebrospinal fluid pleocytosis. The patient tested positive for anti-Tr/Delta/Notch-like epidermal growth factor-related receptor (DNER) antibodies, and a tissue biopsy revealed complications of anaplastic large cell lymphoma. Typically, anti-Tr/DNER antibody-associated paraneoplastic neurological syndrome presents with cerebellar ataxia and is complicated by Hodgkin lymphoma (HL). However, there are rare cases that present only with limbic encephalitis (LE) and are complicated by tumors other than HL; therefore, aggressive antibody measurement and search for tumors are important.

Indexed as

AutoantibodiesLimbic EncephalitisLymphoma, Large-Cell, AnaplasticParaneoplastic Syndromes, Nervous SystemAged, 80 and overHumansMagnetic Resonance ImagingMaleAutoantibodiesanaplastic large cell lymphomaanti-Tr/DNER antibodylimbic encephalitisparaneoplastic cerebellar degenerationparaneoplastic neurologic syndrome

Identifiers

PMID39662912
PMCPMC12287585

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.