Evidence map›Paper›PMID 39662689›Full record

ArticleFree radical biology & medicine2025

Selenoproteome depletion enhances oxidative stress and alters neutrophil functions in Citrobacter rodentium infection leading to gastrointestinal inflammation.

Tai-Jung Lee, Hsiao-Chi Liao, Agus Salim, Shaneice K Nettleford, Kendall L Kleinman, Bradley A Carlson, K Sandeep Prabhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Redox Modulation of Erythropoiesis by Selenoproteins.Biological trace element research · 2026
    Review
  2. Selenium and Selenoproteins in Neutrophil Functions.Biological trace element research · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tai-Jung LeeDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, 107D Animal, Veterinary and Biomedical Sciences Building, University Park, PA 16801, USA.
Hsiao-Chi LiaoSchool of Mathematics and Statistics and Melbourne School of Population and Global Health, University of Melbourne, Grattan Street, Parkville, Victoria, 3010, Australia.
Agus SalimSchool of Mathematics and Statistics and Melbourne School of Population and Global Health, University of Melbourne, Grattan Street, Parkville, Victoria, 3010, Australia.
Shaneice K NettlefordDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, 107D Animal, Veterinary and Biomedical Sciences Building, University Park, PA 16801, USA.
Kendall L KleinmanDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, 107D Animal, Veterinary and Biomedical Sciences Building, University Park, PA 16801, USA.
Bradley A CarlsonMolecular Biology of Selenium Section, Mouse Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
K Sandeep PrabhuDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, 107D Animal, Veterinary and Biomedical Sciences Building, University Park, PA 16801, USA. Electronic address: ksp4@psu.edu.

Funding

Cellular Selenium Status and PGJ2 Metabolism (PA-17-078 supplement 2017)R01DK077152 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PRABHU, KUMBLE SANDEEP · 2008 to 2018
$2.5M
Cellular selenium and PGJ2 metabolismR56DK077152 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PRABHU, KUMBLE SANDEEP · 2021 to 2021
$386k
NIDDK NIH HHS R01 DK077152NIDDK NIH HHS R56 DK077152
6 · The paper itself

Abstract

Reactive oxygen species (ROS) play a critical role in modulating a range of proinflammatory functions in neutrophils, as well as regulating neutrophil apoptosis and facilitating the resolution of an inflammatory response. Selenoproteins with the 21st amino acid, selenocysteine (Sec), regulate immune mechanisms through the modulation of redox homeostasis aiding in the efficient resolution of inflammation, while their role in neutrophil functions during diseases remains unclear. To study the role of selenoproteins in neutrophils during infection, we challenged the granulocyte-specific tRNA

Indexed as

Citrobacter rodentiumEnterobacteriaceae InfectionsNeutrophilsRNA, Transfer, Amino Acid-SpecificSelenoproteinsAnimalsApoptosisColonInflammationMiceMice, Inbred C57BLMice, KnockoutOxidative StressReactive Oxygen SpeciesReactive Oxygen SpeciesRNA, Transfer, Amino Acid-SpecificSelenoproteinstRNA, selenocysteine-ApoptosisEfferocytosisMigrationReactive oxygen speciesResolution

Identifiers

PMID39662689
PMCPMC11757042

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.