Evidence map›Paper›PMID 39662616›Full record

ArticleJournal of vascular and interventional radiology : JVIR2025

Histotripsy of the Proximal Ureter and Renal Pelvis: Evaluation of Urothelial Injury in a Porcine Survival Model.

Adrienne L Kisting, Annie M Zlevor, Katrina L Falk, Meridith A Kisting, Israa A Laklouk, Martin G Wagner, Jim K White, J Erik Winterholler, Madeline S Jentink, E Jason Abel and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular and interventional radiology : JVIR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Adrienne L KistingDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Annie M ZlevorDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Katrina L FalkDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin.
Meridith A KistingDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Israa A LakloukDepartment of Anatomic Pathology, University of California, Los Angeles, Los Angeles, California.
Martin G WagnerDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin; Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin.
Jim K WhiteDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
J Erik WinterhollerDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Madeline S JentinkDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
E Jason AbelDepartment of Urology, University of Wisconsin-Madison, Madison, Wisconsin.
Erica M Knavel KoepselDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
J Louis HinshawDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin; Department of Urology, University of Wisconsin-Madison, Madison, Wisconsin.
John F SwietlikDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Lu MaoDepartment of Biostatistics, University of Wisconsin-Madison, Madison, Wisconsin.
Grace M MinesingerDepartment of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin.
Paul F LaesekeDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin.
Timothy J ZiemlewiczDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin.
Fred T LeeDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin; Department of Urology, University of Wisconsin-Madison, Madison, Wisconsin. Electronic address: ftlee@wisc.edu.

Funding

Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Advanced multimodal image-guided histotripsy for precise, safe and effective histotripsy of liver tumorsR01EB031007 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F Laeseke, Martin Gerd Wagner · 2022 to 2026
$2.5M
Developing Methods for Precise, Safe and Target-location Specific Histotripsy of Liver TumorsR01CA262474 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ZIEMLEWICZ, TIMOTHY J · 2021 to 2025
$2.4M
Developing an Accurate and Robust Targeting Technique to Enable Transcostal Histotripsy Treatment of Liver TumorsF30CA284541 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Katrina Lauren Falk · 2024 to 2026
$135k
NCI NIH HHS F30 CA284541NCI NIH HHS R01 CA262474NIBIB NIH HHS R01 EB031007NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

purposeTo evaluate the response of the ureter and renal pelvis to direct targeting by histotripsy guided by cone-beam computed tomography (CT) in a human-scale porcine chronic-survival model. MATERIALS AND

methodsBilateral ureteral histotripsy treatments were completed on 6 female swine (n = 12). Animals were divided into 2 groups: (a) acute (n = 2 animals, 4 treatments, sacrificed at Day 0) and (b) chronic (n = 4 animals, 8 treatments, sacrificed at Day 7 [n = 2] and Day 28 [n = 2]). For each treatment, a 2.5-cm sphere (ureter/renal pelvis and renal parenchyma) was targeted using cone-beam CT guidance. CT urography imaging was performed immediately after treatment for all animals, and on Days 7 and 28 for chronic animals, followed by sacrifice, necropsy, and histopathology. Serum chemistries were drawn before treatment and at Days 7 and 28.

resultsAll 12 treatments were successful in targeting the renal pelvis/ureter and renal parenchyma. CT urography findings at Day 0 included ureteral thickening (9/12), delayed parenchymal enhancement (3/12), and mild hydronephrosis (5/12), all resolving by Day 7. Histologic findings of low-grade damage resolved by Day 7. No urine leaks or ureteral strictures were observed. Renal function (creatinine and estimated glomerular filtration rate) remained within the normal range throughout the study.

conclusionsHistotripsy treatment of the ureter and renal pelvis results in transient injuries, suggesting that treatment of central renal tumors adjacent to the ureter and renal pelvis is safe. The results of this study could help expand the range of renal tumors that can be treated with histotripsy.

Indexed as

Kidney PelvisLithotripsyUreterUrotheliumAnimalsCone-Beam Computed TomographyDisease Models, AnimalFemaleRadiography, InterventionalSwineTime FactorsUrography

Identifiers

PMID39662616
PMCPMC12067682

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.