Evidence map›Paper›PMID 39662516›Full record

ArticleNMR in biomedicine2025

A Water Relaxation Atlas for Age- and Region-Specific Metabolite Concentration Correction at 3 T.

Gizeaddis Lamesgin Simegn, Yulu Song, Saipavitra Murali-Manohar, Helge J Zöllner, Christopher W Davies-Jenkins, Dunja Simicic, Kathleen E Hupfeld, Aaron T Gudmundson, Emlyn Muska, Emily Carter and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gizeaddis Lamesgin SimegnThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yulu SongThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Saipavitra Murali-ManoharThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Helge J ZöllnerThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7148-292X
Christopher W Davies-JenkinsThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Dunja SimicicThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-6600-2696
Kathleen E HupfeldThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-5086-4841
Aaron T GudmundsonThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Emlyn MuskaCenter for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
Emily CarterCenter for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
Steve C N HuiDeveloping Brain Institute, Children's National Hospital, Washington, DC, USA.
Vivek YedavalliThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Georg OeltzschnerThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3083-9811
Douglas C DeanWaisman Center, University of WI-Madison, Madison, Wisconsin, USA.
Can CeritogluCenter for Imaging Science and Institute for Computational Medicine, Department of Biomedical Engineering, JHU, Baltimore, Maryland, USA.
J Tilak RatnanatherF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
Eric PorgesCenter for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
Richard EddenThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Peter CM Van Zijl · 2021 to 2026
$9.9M
Novel Extensions of Alcohol Contingency Management in People Living with HIVP01AA029543 · NIAAA · UNIVERSITY OF FLORIDA · PI LI, ZHIGANG · 2021 to 2025
$6.6M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
WISE II - Obesity and Type-2 Diabetes: Bariatric Surgery Effects on Brain FunctionR01DK099334 · NIDDK · UNIVERSITY OF FLORIDA · PI RONALD A COHEN, Eric Porges · 2014 to 2026
$4.6M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
Edited Magnetic Resonance Spectroscopy of the Pediatric BrainR01EB032788 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2023 to 2026
$2.7M
Model Selection for Magnetic Resonance SpectroscopyR01EB035529 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Georg Oeltzschner · 2024 to 2026
$1.7M
Towards a comprehensive neurometabolic profile in patients with mild cognitive impairment.R00AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2021 to 2023
$735k
General Linear Modeling For Magnetic Resonance SpectroscopyR21EB033516 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2022 to 2024
$670k
Cortical Inhibition and Mobility in Older AdultsK00AG068440 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUPFELD, KATHLEEN ELIZABETH · 2022 to 2024
$222k
Brain metabolism across the lifespan using multi-parametric MRSK99AG080084 · NIA · JOHNS HOPKINS UNIVERSITY · PI ZOELLNER, HELGE JOERN · 2023 to 2024
$212k
NIAAA NIH HHS P01 AA029543NIA NIH HHS K00 AG068440NIA NIH HHS K99 AG080084NIA NIH HHS R00 AG062230NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NIBIB NIH HHS R01 EB032788NIBIB NIH HHS R01 EB035529NIBIB NIH HHS R21 EB033516NIDDK NIH HHS R01 DK099334NIH HHS K00 AG068440NIH HHS K99 AG080084NIH HHS P01AA029543NIH HHS P41 EB031771NIH HHS R00 AG062230NIH HHS R01DK099334NIH HHS R01 EB016089NIH HHS R01 EB023963NIH HHS R01 EB032788NIH HHS R01 EB035529NIH HHS R21 EB033516
6 · The paper itself

Abstract

Metabolite concentration estimates from magnetic resonance spectroscopy (MRS) are typically quantified using water referencing, correcting for relaxation-time differences between metabolites and water. One common approach is to correct the reference signal for differential relaxation within three tissue compartments (gray matter, white matter, and cerebrospinal fluid) using fixed literature values. However, water relaxation times (T

Indexed as

BrainWaterAdultAgingAtlases as TopicFemaleHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedYoung AdultWateragingbrain parcelsmetabolite quantificationMRSrelaxation timesRelaxometry atlas

Identifiers

PMID39662516
PMCPMC12127971

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.