Evidence map›Paper›PMID 39662508›Full record

ArticleNature2025

Discovery and engineering of the antibody response to a prominent skin commensal.

Djenet Bousbaine, Katherine D Bauman, Y Erin Chen, Pranav V Lalgudi, Tam T D Nguyen, Joyce M Swenson, Victor K Yu, Eunice Tsang, Sean Conlan, David B Li and 19 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Review
  3. Germinal center responses at barrier organ sites.Current opinion in immunology · 2026
    Review
  4. Review
  5. Biologics for cardiovascular diseases: from bench to bedside.Signal transduction and targeted therapy · 2026
    Review
  6. Article
  7. Article
  8. Hidden immune memory niches in inflammatory skin diseases.bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Journal of bacteriology · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. B cells in non-lymphoid tissues.Nature reviews. Immunology · 2025
    Review
  20. Designing live bacterial therapeutics for cancer.Advanced drug delivery reviews · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Djenet BousbaineDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0003-2683-9544
Katherine D BaumanDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Y Erin ChenDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Pranav V LalgudiChEM-H Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1653-2338
Tam T D NguyenDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Joyce M SwensonDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Victor K YuDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Eunice TsangDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Sean ConlanMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
David B LiDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8921-5168
Amina JbaraDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Aishan ZhaoDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Arash NaziripourDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Alessandra VeinbachsDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Yu E LeeChEM-H Institute, Stanford University, Stanford, CA, USA.
Jennie L PhungChEM-H Institute, Stanford University, Stanford, CA, USA.
Alex DimasDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Sunit JainChan Zuckerberg Biohub, Stanford, CA, USA.ORCID 0000-0002-5888-3702
Xiandong MengChEM-H Institute, Stanford University, Stanford, CA, USA.
Thi Phuong Thao PhamDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Martin I McLaughlinDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4410-0786
Layla J BarkalDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Inta GribonikaMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5694-1315
Koen K A Van RompayCalifornia National Primate Research Center, University of California, Davis, CA, USA.ORCID 0000-0002-7375-1337
Heidi H KongDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4424-064X
Julia A SegreMicrobial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6860-348X
Yasmine BelkaidMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9962-3571
Christopher O BarnesChEM-H Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0003-2754-5951
Michael A FischbachDepartment of Bioengineering, Stanford University, Stanford, CA, USA. fischbach@fischbachgroup.org.ORCID 0000-0003-3079-8247

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Building the foundations of commensal vaccinesR01AI175642 · NIAID · STANFORD UNIVERSITY · PI MICHAEL ANDREW FISCHBACH · 2022 to 2026
$3.8M
30-parameter FACSymphony A3 flow cytometer for Shared Resource LabS10OD026831 · OD · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2019 to 2019
$510k
Probing and engineering the B cell response to the skin microbiotaK99AI180358 · NIAID · STANFORD UNIVERSITY · PI BOUSBAINE, DJENET · 2024 to 2025
$262k
Commensal bacteria as vehicles for robust mucosal vaccination against lung pathogensF32HL170591 · NHLBI · STANFORD UNIVERSITY · PI BARKAL, LAYLA · 2023 to 2023
$81k
NHLBI NIH HHS F32 HL170591NIAID NIH HHS K99 AI180358NIAID NIH HHS R01 AI175642NIAID NIH HHS U19 AI057229NIH HHS P51 OD011107NIH HHS S10 OD026831
6 · The paper itself

Abstract

The ubiquitous skin colonist Staphylococcus epidermidis elicits a CD8

Indexed as

Antibodies, BacterialSkinStaphylococcus epidermidisSymbiosisAnimalsAntibodies, NeutralizingAntibody FormationBacterial ProteinsB-LymphocytesCD8-Positive T-LymphocytesFemaleHumansImmunoglobulin AMaleMiceMice, Inbred C57BLAntibodies, BacterialAntibodies, NeutralizingBacterial ProteinsImmunoglobulin ATetanus Toxin

Identifiers

PMID39662508
PMCPMC12045117

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.