Evidence map›Paper›PMID 39662505›Full record

ArticleNature2025

Structure and mechanism of the Zorya anti-phage defence system.

Haidai Hu, Philipp F Popp, Thomas C D Hughes, Aritz Roa-Eguiara, Nicole R Rutbeek, Freddie J O Martin, Ivo Alexander Hendriks, Leighton J Payne, Yumeng Yan, Dorentina Humolli and 9 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Advances in understanding Ton and Tol system motor proteins.Biochemical Society transactions · 2026
    Review
  15. Review
  16. Review
  17. Genomic islands inNAR genomics and bioinformatics · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Haidai Hu *Structural Biology of Molecular Machines Group, Protein Structure & Function Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. haidai.hu@cpr.ku.dk.ORCID 0000-0001-7774-9157
Philipp F Popp *Institute of Biology/Molecular Microbiology, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-7825-1550
Thomas C D HughesDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.ORCID 0009-0005-6057-4852
Aritz Roa-EguiaraStructural Biology of Molecular Machines Group, Protein Structure & Function Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3962-7583
Nicole R RutbeekStructural Biology of Molecular Machines Group, Protein Structure & Function Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-6851-8223
Freddie J O MartinStructural Biology of Molecular Machines Group, Protein Structure & Function Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-6456-2860
Ivo Alexander HendriksProteomics program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-1439-3701
Leighton J PayneDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.ORCID 0000-0003-2305-6827
Yumeng YanStructural Biology of Molecular Machines Group, Protein Structure & Function Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Dorentina HumolliInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.ORCID 0009-0002-1819-6155
Victor Klein-SousaStructural Biology of Molecular Machines Group, Protein Structure & Function Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-0430-4330
Inga SongailieneStructural Biology of Molecular Machines Group, Protein Structure & Function Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Yong WangCollege of Life Sciences, Zhejiang University, Hangzhou, China.ORCID 0000-0001-9156-0377
Michael Lund NielsenProteomics program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-0067-9039
Richard M BerryDepartment of Physics and Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.ORCID 0000-0002-0331-473X
Alexander HarmsInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.ORCID 0000-0003-2106-1286
Marc ErhardtInstitute of Biology/Molecular Microbiology, Humboldt-Universität zu Berlin, Berlin, Germany. marc.erhardt@hu-berlin.de.ORCID 0000-0001-6292-619X
Simon A JacksonDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand. simon.jackson@otago.ac.nz.ORCID 0000-0002-4512-3093
Nicholas M I TaylorStructural Biology of Molecular Machines Group, Protein Structure & Function Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. nicholas.taylor@cpr.ku.dk.ORCID 0000-0003-0761-4921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zorya is a recently identified and widely distributed bacterial immune system that protects bacteria from viral (phage) infections. Three Zorya subtypes have been identified, each containing predicted membrane-embedded ZorA-ZorB (ZorAB) complexes paired with soluble subunits that differ among Zorya subtypes, notably ZorC and ZorD in type I Zorya systems

Indexed as

Bacterial ProteinsBacteriophagesEscherichia coliCryoelectron MicroscopyDNA-Binding ProteinsModels, MolecularPeptidoglycanBacterial ProteinsDNA-Binding ProteinsPeptidoglycan

Identifiers

PMID39662505
PMCPMC11946911

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.