Evidence map›Paper›PMID 39662499›Full record

ArticleJournal of Korean medical science2024

Single-Dose Versus Multiple-Dose Prophylactic Antibiotics in Minimally Invasive Colorectal Surgery: A Propensity Score Matched Analysis.

Ga Yoon Ku, Beom-Jin Kim, Ji Won Park, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ga Yoon KuDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-2051-3201
Beom-Jin KimDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0009-0001-7609-3106
Ji Won ParkDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-0046-8175
Min Jung KimDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-3105-9633
Seung-Bum RyooDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-6407-0444
Seung-Yong JeongDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-2726-4850
Kyu Joo ParkDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-9134-7426

Funding

Ministry of Health and Welfare HI23C159101Ministry of Health and Welfare RS-2023-CC140354
6 · The paper itself

Abstract

backgroundRecent guidelines about preventing surgical site infections (SSIs) recommend against the administration of prophylactic antibiotics after surgery. However, many colorectal surgeons still prefer prolonged use of prophylactic antibiotics. While minimally invasive surgery (MIS) has become the standard for colorectal cancer surgery, there were few studies about proper dose of prophylactic antibiotics in minimally invasive colorectal surgery.

methodsThis is a retrospective study. All patients underwent elective colorectal cancer surgery using MIS. Intravenous cefotetan was administered as a prophylactic antibiotic. Two groups were classified according to the dose of prophylactic antibiotics: a group using a single dose preoperatively (single-dose group) and a group using a preoperative single dose plus additional doses within 24 hours after surgery (multiple-dose group). The SSI rates between the two groups were compared before and after propensity score matching (PSM). Risk factors of SSIs were assessed using univariate and multivariable analysis.

resultsThere were 902 patients in the single-dose group and 330 patients in the multiple-dose group. After PSM, 320 patients were included in each group. There were no differences in baseline characteristics and surgical outcomes except the length of hospital stay. SSI rates were not different between the two groups before and after PSM (before 2.0% vs. 2.1%,

conclusionA single preoperative dose of prophylactic antibiotics may be sufficient to prevent SSIs in elective MIS for colorectal cancer.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisColorectal NeoplasmsMinimally Invasive Surgical ProceduresPropensity ScoreSurgical Wound InfectionAgedCefotetanColorectal SurgeryFemaleHumansLength of StayMaleMiddle AgedOdds RatioRetrospective StudiesAnti-Bacterial AgentsCefotetanCefotetanMinimally Invasive Colorectal SurgeryProphylactic AntibioticsSingle Preoperative DoseSingle Preoperative Dose + Multiple Postoperative DosesSurgical Site Infection (SSI)

Identifiers

PMID39662499
PMCPMC11628240

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.