Evidence map›Paper›PMID 39662085›Full record

ArticleImmunity2024

Gasping for air: HIF2α in asthma.

Shilpi Giri, Amanda C Poholek

Abstract readComment
In one paragraph

Article in Immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Shilpi GiriCenter for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Amanda C PoholekCenter for Systems Immunology, Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: poholeka@pitt.edu.

Funding

Role of T-bet in the pathogenesis of experimental autoimmune encephalomyelitisZIABC011431 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LAZAREVIC, VANJA · 2012 to 2025
$9.7M
Transcriptional regulation of inflammatory and autoimmune responsesZIABC011765 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LAZAREVIC, VANJA · 2017 to 2025
$7.7M
Lung-specific expression and function of Blimp-1 in T cells impacting allergic asthmaR01AI153104 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POHOLEK, AMANDA CATHERINE · 2021 to 2025
$2.6M
Dissecting the role of hypoxia in T cell differentiation in cancerR01CA277473 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Greg M. Delgoffe, Yana Najjar · 2023 to 2026
$2.4M
Tissue-specific mediators of allergen-driven type 2 inflammationR21AI156093 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POHOLEK, AMANDA CATHERINE · 2021 to 2022
$379k
Intramural NIH HHS ZIA BC011431Intramural NIH HHS ZIA BC011765NCI NIH HHS R01 CA277473NIAID NIH HHS R01 AI153104NIAID NIH HHS R21 AI156093
6 · The paper itself

Abstract

Despite protective roles in various type of infection and in would healing, T helper (Th)2 cells are drivers of inflammation in allergic asthma. In this issue of Immunity, Zou et al. demonstrate the crucial involvement of hypoxia inducible factor (HIF)2α in promoting the differentiation of inflammatory Th2 cells, suggesting HIF2α as a promising therapeutic target for the treatment of allergic asthma.

Identifiers

PMID39662085
PMCPMC11891762

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.