Evidence map›Paper›PMID 39661794›Full record

ArticleBrazilian oral research2024

Mast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma.

Isadora Luana Flores, José Alcides Almeida de Arruda, Thamiris de Castro Abrantes, Thiago de Oliveira Gamba, Aline Correa Abrahão, Ana Lia Anbinder, Jaqueline Lemes Ribeiro, Ana Carolina Uchoa Vasconcelos, Bruno Augusto Benevenuto de Andrade, Maria Cassia Ferreira de Aguiar and 3 more

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Article in Brazilian oral research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Isadora Luana FloresUniversidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry, Department of Oral Pathology, Porto Alegre, RS, Brazil.ORCID 0000-0002-6628-2122
José Alcides Almeida de ArrudaUniversidade Federal do Rio de Janeiro - UFRJ, School of Dentistry, Department of Oral Diagnosis and Pathology, Rio de Janeiro, RJ, Brazil.ORCID 0000-0002-6599-3950
Thamiris de Castro AbrantesUniversidade Federal do Rio de Janeiro - UFRJ, School of Dentistry, Department of Oral Diagnosis and Pathology, Rio de Janeiro, RJ, Brazil.ORCID 0000-0002-9382-912X
Thiago de Oliveira GambaUniversidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry, Department of Oral Radiology, Porto Alegre, RS, Brazil.ORCID 0000-0002-3941-9672
Aline Correa AbrahãoUniversidade Federal do Rio de Janeiro - UFRJ, School of Dentistry, Department of Oral Diagnosis and Pathology, Rio de Janeiro, RJ, Brazil.ORCID 0000-0002-3397-3234
Ana Lia AnbinderUniversidade Estadual Paulista - Unesp, Institute of Science and Technology, Department of Biosciences and Oral Diagnosis, São José dos Campos, SP, Brazil.ORCID 0000-0003-3930-4274
Jaqueline Lemes RibeiroUniversidade Estadual Paulista - Unesp, Institute of Science and Technology, Department of Biosciences and Oral Diagnosis, São José dos Campos, SP, Brazil.ORCID 0000-0001-6574-7701
Ana Carolina Uchoa VasconcelosUniversidade Federal de Pelotas - UFPel, School of Dentistry, Diagnostic Center for Oral Diseases, Pelotas, RS, Brazil.ORCID 0000-0001-6560-9536
Bruno Augusto Benevenuto de AndradeUniversidade Federal do Rio de Janeiro - UFRJ, School of Dentistry, Department of Oral Diagnosis and Pathology, Rio de Janeiro, RJ, Brazil.ORCID 0000-0002-3259-606X
Maria Cassia Ferreira de AguiarUniversidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery, Pathology and Clinical Dentistry, Belo Horizonte, MG, Brazil.ORCID 0000-0001-5134-3466
Ana Paula Neutzling GomesUniversidade Federal de Pelotas - UFPel, School of Dentistry, Diagnostic Center for Oral Diseases, Pelotas, RS, Brazil.ORCID 0000-0003-2214-5246
Lucas Guimarães AbreuUniversidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Child and Adolescent Oral Health, Belo Horizonte, MG, Brazil.ORCID 0000-0003-2258-8071
Ricardo Alves MesquitaUniversidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Oral Surgery, Pathology and Clinical Dentistry, Belo Horizonte, MG, Brazil.ORCID 0000-0003-3207-4007

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is an interaction between dendrocytes and mast cells in the skin. However, in elastosis-related diseases such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC), this interaction remains unknown. We investigated the presence of intact and degranulated mast cells in AC and LLSCC. Associations of mast cells with factor XIIIa+ dendrocytes and inflammatory infiltrate were assessed. Forty cases of AC (20 with low-grade and 20 with high-grade epithelial dysplasia), 50 cases of LLSCC, and 10 cases of normal oral mucosa were evaluated. Toluidine blue staining was performed to identify mast cells, and mast cell densities were calculated in the inflammatory infiltrate. Factor XIIIa+ dendrocytes were immunohistochemically quantified. The highest ratio of intact/degranulated mast cells density was detected in LLSCC (5.9 cells/mm2), followed by AC with high-grade epithelial dysplasia (4.8 cells/mm2). Statistically significant differences were found in the density of intact mast cells compared to degranulated mast cells in AC with low-grade epithelial dysplasia (p<0.001), AC with high-grade epithelial dysplasia (p=0.005), and LLSCC (p<0.001). A positive correlation between degranulated mast cells and total inflammatory infiltrate (p=0.03) was observed in the LLSCC group. The expression of factor XIIIa+ dendrocytes was highest in AC with low-grade epithelial dysplasia (16.5 cells/mm2). The link between mast cell density, factor XIIIa+ dendrocytes, and inflammatory infiltrate indicates a potential crosstalk in lip carcinogenesis.

Indexed as

Carcinoma, Squamous CellCheilitisImmunohistochemistryLip NeoplasmsMast CellsMouth MucosaAdultAgedCase-Control StudiesCell CountDendritic CellsFemaleHumansMaleMiddle AgedReference Values

Identifiers

PMID39661794
PMCPMC11654881

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.