ArticleBrazilian oral research2024
Antimicrobial activity of PMMA enriched with nano-clay loaded with metronidazole and chlorhexidine.
Article in Brazilian oral research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- A multi-modal strategy for enhancing titanium-bone interface strength and antimicrobial properties of PMMA bone cements.Materials & design · 2026Article
- Improving Bonding Durability in Dental Restorations: The Impact of Bioactive and Reinforcement Particles on Universal Adhesives.Materials (Basel, Switzerland) · 2025Article
- Cross-Linked Poly(methyl methacrylate) Nanocomposites' Synthesis, Characterization, and Antibacterial Effects.Polymers · 2025Article
- Nano-particle coated or impregnated acrylic resins in dental applications: A systematic review of in Vivo Evidence on mechanical properties, biocompatibility and clinical performance.Journal of oral biology and craniofacial researchReview
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poly(methyl methacrylate) (PMMA) materials are highly susceptible to microbial colonization, predisposing patients to oral infections. To address this concern, we loaded PMMA samples with montmorillonite clay (MMT), a crystalline nanoparticle, in combination with chlorhexidine (CHX) or metronidazole (MET) targeting improved antimicrobial action. PMMA samples were prepared with or without MMT loaded with either CHX or MET, establishing the following groups: control (acrylic resin without the addition of nanoparticles), MMT/CHX (acrylic resin with 5% by weight of MMT loaded with CHX), and MMT/MET (acrylic resin with 5% by weight of MMT loaded with MET). Mechanical properties such flexural strength, flexural modulus, and Knoop hardness were evaluated using a universal testing machine. Antimicrobial efficacy was assessed via agar diffusion tests against Enterococcus faecalis and Porphyromonas gingivalis. The addition of MMT loaded with CHX did not affect the flexural strength and flexural modulus of PMMA compared to the control group (p > 0.05). However, MMT/MET reduced all mechanical properties of PMMA (p < 0.05). Both loaded-PMMA materials demonstrated antibacterial activity against E. faecalis but not against P. gingivalis. In conclusion, the incorporation of MMT/CHX into acrylic resin appears to be the most promising approach to combat microbial colonization while preserving PMMA mechanical properties. Future research should focus on optimizing material characteristics to enhance antimicrobial properties, paving the way for clinical applicability.
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