Evidence map›Paper›PMID 39661693›Full record

ArticleScience advances2024

Framework nucleic acid strategy enables closer microbial contact for programming short-range interaction.

Na Chen, Jing Xi, Na Du, Ruichen Shen, Rui Zhao, Wei He, Tianhuang Peng, Yanbing Yang, Yun Zhang, Lilei Yu and 2 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Na ChenRenmin Hospital of Wuhan University, College of Chemistry and Molecular Sciences, Institute of Molecular Medicine, School of Microelectronics, Wuhan University, Wuhan 430072, P. R. China.ORCID 0009-0000-6115-2698
Jing XiRenmin Hospital of Wuhan University, College of Chemistry and Molecular Sciences, Institute of Molecular Medicine, School of Microelectronics, Wuhan University, Wuhan 430072, P. R. China.ORCID 0009-0002-5822-9038
Na DuRenmin Hospital of Wuhan University, College of Chemistry and Molecular Sciences, Institute of Molecular Medicine, School of Microelectronics, Wuhan University, Wuhan 430072, P. R. China.ORCID 0009-0004-7807-6918
Ruichen ShenMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.
Rui ZhaoRenmin Hospital of Wuhan University, College of Chemistry and Molecular Sciences, Institute of Molecular Medicine, School of Microelectronics, Wuhan University, Wuhan 430072, P. R. China.ORCID 0009-0007-9323-2597
Wei HeRenmin Hospital of Wuhan University, College of Chemistry and Molecular Sciences, Institute of Molecular Medicine, School of Microelectronics, Wuhan University, Wuhan 430072, P. R. China.ORCID 0009-0007-9477-1445
Tianhuang PengMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.ORCID 0000-0002-2229-2687
Yanbing YangRenmin Hospital of Wuhan University, College of Chemistry and Molecular Sciences, Institute of Molecular Medicine, School of Microelectronics, Wuhan University, Wuhan 430072, P. R. China.ORCID 0000-0001-7461-0125
Yun ZhangState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China.ORCID 0000-0001-6288-4671
Lilei YuRenmin Hospital of Wuhan University, College of Chemistry and Molecular Sciences, Institute of Molecular Medicine, School of Microelectronics, Wuhan University, Wuhan 430072, P. R. China.ORCID 0000-0001-9229-2829
Weihong TanMolecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.ORCID 0000-0002-8066-1524
Quan YuanRenmin Hospital of Wuhan University, College of Chemistry and Molecular Sciences, Institute of Molecular Medicine, School of Microelectronics, Wuhan University, Wuhan 430072, P. R. China.ORCID 0000-0002-3085-431X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Programming precise and specific microbial intraspecies or interspecies interaction would be powerful for microbial metabolic regulation, signal pathway mechanism understanding, and therapeutic application. However, it is still of great challenge to develop a simple and universal method to artificially encode the microbial interactions without interfering with the intrinsic cell metabolism. Here, we proposed an extensible and flexible framework nucleic acid strategy for encoding the specific and precise microbial interactions upon self-assembly. With this spatial manipulation tool, we propose the microbial spatial heterogeneity and short-range interaction mechanism that the microbial assembly facilitates the gene expressions of the surface sensors including flagella and pili in

Indexed as

Nucleic AcidsPseudomonas aeruginosaQuorum SensingFimbriae, BacterialFlagellaGene Expression Regulation, BacterialMicrobial InteractionsNucleic Acids

Identifiers

PMID39661693
PMCPMC11633756

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.