Evidence map›Paper›PMID 39661692›Full record

ArticleScience advances2024

Electrochemical imaging of neurotransmitter release with fast-scan voltammetric ion conductance microscopy.

Yunong Wang, Cristobal Rodriguez, Sasha E Alden, Myung-Hoon Choi, Kristen Alanis, Rahul Srinivasan, Lane A Baker

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yunong WangDepartment of Chemistry, Texas A&M University, College Station, TX 77845-3255, USA.ORCID 0000-0003-1327-4994
Cristobal RodriguezDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University College of Medicine, Bryan, TX 77807, USA.ORCID 0000-0003-1836-1923
Sasha E AldenDepartment of Chemistry, Texas A&M University, College Station, TX 77845-3255, USA.ORCID 0000-0002-7274-9139
Myung-Hoon ChoiPark Systems Inc, Santa Clara, CA 95054, USA.ORCID 0000-0003-4985-8924
Kristen AlanisDepartment of Chemistry, Texas A&M University, College Station, TX 77845-3255, USA.ORCID 0000-0001-9044-0752
Rahul SrinivasanDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University College of Medicine, Bryan, TX 77807, USA.ORCID 0000-0003-0237-6602
Lane A BakerDepartment of Chemistry, Texas A&M University, College Station, TX 77845-3255, USA.ORCID 0000-0001-5127-507X

Funding

Identification of mechanisms by which cytisine and estrogen inhibit ER stress and exert neuroprotection in Parkinson's diseaseR01NS115809 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SRINIVASAN, RAHUL · 2020 to 2024
$1.7M
NINDS NIH HHS R01 NS115809
6 · The paper itself

Abstract

Understanding the dynamic spatial and temporal release of neurotransmitters can help resolve long-standing questions related to chemical modulation of neurological circuits. Dopamine modulates function in a range of physiological processes and is key to transmission in addiction and neurological disorders. Studies at subcellular scales promise to help develop a broader understanding of dopamine release, diffusion, and receptor activation and how these processes lead to functional outcomes. Electrochemical measurements of dopamine release at individual cells have proven especially informative. We describe incorporation of fast-scan cyclic voltammetry for detection of dopamine release with subcellular spatial resolution and millisecond time resolution. The platform is benchmarked with standard redox probes and then applied to imaging stimulated release from subcellular locations of a coculture of dopaminergic neurons and astrocytes. Voltammetry reveals heterogeneity in release based on time, location, and neuron identity. We believe that this platform ultimately offers a window to understanding neurotransmission in pathophysiological models of disease where cell-cell communication is key.

Indexed as

AstrocytesDopamineNeurotransmitter AgentsAnimalsCoculture TechniquesDopaminergic NeuronsElectrochemical TechniquesHumansMicroscopyRatsSynaptic TransmissionDopamineNeurotransmitter Agents

Identifiers

PMID39661692
PMCPMC11633752

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.