Evidence map›Paper›PMID 39661678›Full record

ArticleScience advances2024

From synthetic vesicles to living cells: Anchoring conducting polymers to cell membrane.

Hanne Biesmans, Alex Bersellini Farinotti, Tobias Abrahamsson, Katriann Arja, Caroline Lindholm, Xenofon Strakosas, Jennifer Y Gerasimov, Daniel T Simon, Camilla I Svensson, Chiara Musumeci and 1 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Recent Advances and Future Prospects in Biological-Membrane-Targeted Polymers.Polymer science & technology (Washington, D.C.) · 2025
    Review
  7. Article
  8. Review
  9. Bioresorbable electrodes in implantable electronic healthcare devices.Frontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hanne BiesmansLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-60174 Norrkoping, Sweden.ORCID 0000-0001-6124-4250
Alex Bersellini FarinottiDepartment of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 17176 Stockholm, Sweden.ORCID 0000-0002-3607-1332
Tobias AbrahamssonLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-60174 Norrkoping, Sweden.ORCID 0000-0002-3615-1850
Katriann ArjaLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-60174 Norrkoping, Sweden.
Caroline LindholmLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-60174 Norrkoping, Sweden.ORCID 0000-0001-8961-3193
Xenofon StrakosasLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-60174 Norrkoping, Sweden.ORCID 0000-0001-5757-8565
Jennifer Y GerasimovLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-60174 Norrkoping, Sweden.ORCID 0000-0003-2974-0881
Daniel T SimonLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-60174 Norrkoping, Sweden.ORCID 0000-0002-2799-3490
Camilla I SvenssonDepartment of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 17176 Stockholm, Sweden.ORCID 0000-0001-7980-4631
Chiara MusumeciLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-60174 Norrkoping, Sweden.ORCID 0000-0001-7923-8086
Magnus BerggrenLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, SE-60174 Norrkoping, Sweden.ORCID 0000-0001-5154-0291

Funding

European Research Council
6 · The paper itself

Abstract

Coupling biology with electronics is emerging as a transformative approach in developing advanced medical treatments, with examples ranging from implants for treating neurological disorders to biosensors for real-time monitoring of physiological parameters. The electrodes used for these purposes often face challenges such as signal degradation due to biofouling and limited biocompatibility, which can lead to inaccurate readings and tissue damage over time. Conducting organic polymers are a promising alternative because of their mechanical, chemical, and physical properties, which better match the ones of biological systems. They also can be synthesized in vivo to form bio-templated structures through biologically compatible manufacturing processes. Here, we report a method to achieve conductive polymer structures anchored to cell membranes, creating an intimate interface between the polymer electrode and single cells. We show that the polymer is nontoxic to cells and does not interfere with its activation, thereby making this process an interesting alternative to existing materials and electrode techniques.

Indexed as

Cell MembranePolymersAnimalsBiosensing TechniquesElectric ConductivityElectrodesHumansPolymers

Identifiers

PMID39661678
PMCPMC11633735

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.