Evidence map›Paper›PMID 39661674›Full record

ArticleScience advances2024

The adenine nucleotide translocase family underlies cardiac ischemia-reperfusion injury through the mitochondrial permeability pore independently of cyclophilin D.

Pooja Patel, Arielys Mendoza, Daniel Ramirez, Dexter Robichaux, Jeffery D Molkentin, Jason Karch

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
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  4. Review
  5. Article
  6. Phenotypic CRISPR screens identify NLRX1 as an essential activator of the human mitochondrial permeability transition.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pooja PatelDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-2513-8658
Arielys MendozaDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-0137-0620
Daniel RamirezDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0009-0002-9582-3968
Dexter RobichauxDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-4807-459X
Jeffery D MolkentinDepartment of Pediatrics, Cincinnati Children's Hospital and the University of Cincinnati, Cincinnati, OH, USA.ORCID 0000-0002-3558-6529
Jason KarchDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-3023-7469

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Molecular Regulation of Mitochondrial Permeability Transition and its Role in Regulated NecrosisR01HL150031 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Jason Michael Karch · 2020 to 2026
$2.9M
Cardiovascular Research and Drug Development (CRDD) training programT32HL170967 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens, Damian Winston Young · 2024 to 2026
$830k
NCI NIH HHS P30 CA125123NHLBI NIH HHS R01 HL150031NHLBI NIH HHS T32 HL170967
6 · The paper itself

Abstract

The mitochondrial permeability transition pore (mPTP) is implicated in cardiac ischemia-reperfusion (I/R) injury. During I/R, elevated mitochondrial Ca

Indexed as

Mitochondrial ADP, ATP TranslocasesMitochondrial Permeability Transition PoreMyocardial Reperfusion InjuryPeptidyl-Prolyl Isomerase FAnimalsCalciumCyclophilinsMiceMice, KnockoutMitochondria, HeartMitochondrial Membrane Transport ProteinsCalciumCyclophilinsMitochondrial ADP, ATP TranslocasesMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PorePeptidyl-Prolyl Isomerase FPPIF protein, mouse

Identifiers

PMID39661674
PMCPMC11633734

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.