Evidence map›Paper›PMID 39661655›Full record

ArticleThe Journal of infectious diseases2025

Tissue-Resident CD8+ T Cells as Mediators of Protective Immunity in Breast Milk Transmission of Human Cytomegalovirus.

Shara B Legg, David C Moylan, Neema Kamau, Misty P Latting, Dhruv Devdhara, Sunil K Pati, David K Crossman, Suresh B Boppana, Olaf Kutsch, Steffanie Sabbaj

Abstract read
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In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shara B LeggDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
David C MoylanDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Neema KamauDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Misty P LattingDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-8625-1948
Dhruv DevdharaDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0009-0006-1281-9330
Sunil K PatiDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
David K CrossmanDepartment of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-0981-169X
Suresh B BoppanaDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-4785-2767
Olaf KutschDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Steffanie SabbajDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-4052-6819

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
NovaSeq 6000 Sequencing SystemS10OD032422 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CROWLEY, MICHAEL R · 2022 to 2022
$945k
NCI NIH HHS P30 CA013148NIAID NIH HHS P30 AI027767NIH HHS 1R21 1AI134382NIH HHS S10 OD032422NIH, National Institute of Allergy and Infectious Diseases -01NIH, National Institute of Allergy and Infectious Diseases 1S10OD032422NIH, National Institute of Allergy and Infectious Diseases P30 AI27767
6 · The paper itself

Abstract

While the role of breast milk antibodies to protect infants from human cytomegalovirus (HCMV) has been investigated, the role of T-cells has received little attention. We compared the frequency of memory T-cell populations in breast milk between mothers of infants who acquired breast milk HCMV (transmitters) and those with uninfected infants (nontransmitters). Nontransmitter mothers had an increased frequency of CD8+ effector memory T-cells (Tem) in their breast milk. In addition, we describe tissue-resident memory T cells (Trm) in breast milk and demonstrate most were Tem. We present data that nontransmitter mothers have increased frequency of CD8+ Trm in their breast milk when compared to transmitters and that Trm frequency is inversely correlated with breast milk HCMV viral load. Lastly, using scRNA-seq analysis we identified a unique population of T-cells in nontransmitters and demonstrate that these cells comprise CD8+ Trm. These studies suggest that CD8+ Trm may play a role in preventing viral transmission via breast milk to infants.

Indexed as

CD8-Positive T-LymphocytesCytomegalovirusCytomegalovirus InfectionsInfectious Disease Transmission, VerticalMilk, HumanAdultFemaleHumansImmunologic MemoryInfantInfant, NewbornMemory T CellsViral Loadbreast milkCMVT cellstissue-resident T cells

Identifiers

PMID39661655
PMCPMC12128083

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.