Trial reportEuropean heart journal2025
Mediterranean diet, neutrophil count, and carotid intima-media thickness in secondary prevention: the CORDIOPREV study.
Trial report in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Wine consumption, Mediterranean diet, and cardiovascular risk in two Spanish cohorts.European heart journal · 2026Trial
- Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial.Nature medicine · 2025Trial
- Associations of long-chain and very-long-chain saturated fatty acids with neutrophil related inflammatory markers and insulin resistance markers.Nutrition & diabetes · 2026Article
- Beneficial Effects of Olive Oil and the Mediterranean Diet on Alzheimer's Disease and Vascular Dementia: A Review.Medicina (Kaunas, Lithuania) · 2026Review
- Development and validation of a machine learning-based predictive model for carotid plaque in type 2 diabetes.Frontiers in cardiovascular medicine · 2026Article
- Type 2 diabetes mellitus and incident carotid atherosclerosis: a retrospective cohort study on composite indices.Frontiers in endocrinology · 2026Article
- Triglyceride-glucose index in the associations between chronic low-grade inflammation and carotid intima-media thickness: mediation and effect-modification across triglyceride-glucose strata.BMC cardiovascular disorders · 2025Article
- Protocatechuic Acid Attenuates Inflammation in Macrophage-like Vascular Smooth Muscle Cells in ApoENutrients · 2025Article
- Association of Novel Hematologic Inflammatory Biomarkers with Cardiovascular Disease in Patients with Obstructive Sleep Apnea.Nature and science of sleep · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
BACKGROUND AND
aimsSeveral studies have supported the role of innate immune system as a key factor in the sterile inflammation underlying the pathophysiology of atherosclerosis in mice. However, its involvement in humans remains unclear. This study aimed to explore the association between neutrophil count, and the intima-media thickness of common carotid arteries (IMT-CC), as well as the potential impact of long-term dietary interventions on these associations.
methodsA comprehensive analysis was conducted within the framework of the CORDIOPREV study, a long-term secondary prevention study involving dietary interventions with either a Mediterranean or a low-fat diet. The study evaluated the relationship between absolute neutrophil count and neutrophil-related ratios with IMT-CC at baseline and after 5 and 7 years of dietary intervention.
resultsAt baseline, patients in the highest tertile of neutrophil count had a higher IMT-CC and number of carotid plaques, when compared to lowest tertile (P < .01 and P < .05, respectively). Logistic regression analyses supported this association. Elevated neutrophil count, neutrophil-to-erythrocyte ratio, and neutrophil-to-HDL ratio were associated with an increased likelihood of having an IMT-CC >.9 mm {odds ratio (OR) 1.17 [95% confidence interval (CI) 1.04-1.35], OR 2.21 (95% CI 1.24-4.12), and OR 1.96 (95% CI 1.09-3.55), respectively}, after adjustment for all variables, which was corroborated by linear regression. Furthermore, a linear mixed-effect model analysis from a longitudinal analysis spanning 5 and 7 years revealed an increase in 1 unit of neutrophils/μl at these time points was associated with a mean increase of .004 (.002) mm in the IMT-CC (P = .031) after adjustment for all variables. Interestingly, in patients exhibiting regression in IMT-CC after 7 years of follow-up, those following a Mediterranean diet showed a significant decrease in neutrophil count after 5 and 7 years (both with P < .05), compared to baseline.
conclusionsThese findings suggest that neutrophils may represent a promising target for preventing atherosclerosis. A Mediterranean diet could serve as an effective dietary strategy to reduce neutrophil levels and potentially slow the progression of atherosclerosis, offering a new neutrophil-reducing therapy concept. Further research is essential to gain deeper insights into the role of neutrophils in the pathophysiology of atherosclerotic cardiovascular disease in humans.
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