Evidence map›Paper›PMID 39661394›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Site-Specific Incorporation of Fluorinated Prolines into Proteins and Their Impact on Neighbouring Residues.

Carlos A Elena-Real, Annika Urbanek, Amin Sagar, Priyesh Mohanty, Geraldine Levy, Anna Morató, Aurélie Fournet, Frédéric Allemand, Nathalie Sibille, Jeetain Mittal and 2 more

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carlos A Elena-RealCentre de Biologie Structurale (CBS), Université de Montpellier, INSERM, CNRS, 29 rue de Navacelles, 34090, Montpellier, France.
Annika UrbanekCentre de Biologie Structurale (CBS), Université de Montpellier, INSERM, CNRS, 29 rue de Navacelles, 34090, Montpellier, France.
Amin SagarCentre de Biologie Structurale (CBS), Université de Montpellier, INSERM, CNRS, 29 rue de Navacelles, 34090, Montpellier, France.
Priyesh MohantyArtie McFerrin Department of Chemical Engineering, Texas A&M, College Station, TX 77843, USA.
Geraldine LevyUniv. Lille, INSERM, Institut Pasteur de Lille, CHU Lille, U1167 - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, 59000, Lille, France.
Anna MoratóCentre de Biologie Structurale (CBS), Université de Montpellier, INSERM, CNRS, 29 rue de Navacelles, 34090, Montpellier, France.
Aurélie FournetCentre de Biologie Structurale (CBS), Université de Montpellier, INSERM, CNRS, 29 rue de Navacelles, 34090, Montpellier, France.
Frédéric AllemandCentre de Biologie Structurale (CBS), Université de Montpellier, INSERM, CNRS, 29 rue de Navacelles, 34090, Montpellier, France.
Nathalie SibilleCentre de Biologie Structurale (CBS), Université de Montpellier, INSERM, CNRS, 29 rue de Navacelles, 34090, Montpellier, France.
Jeetain MittalArtie McFerrin Department of Chemical Engineering, Texas A&M, College Station, TX 77843, USA.
Davy SinnaeveUniv. Lille, INSERM, Institut Pasteur de Lille, CHU Lille, U1167 - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, 59000, Lille, France.
Pau BernadóCentre de Biologie Structurale (CBS), Université de Montpellier, INSERM, CNRS, 29 rue de Navacelles, 34090, Montpellier, France.

Funding

Multiscale Computational Models to Investigate the Role of Phase Separation in BiologyR35GM153388 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI Jeetain Mittal · 2024 to 2026
$1.3M
H2020 European Research Council 648030NIGMS NIH HHS R35 GM153388
6 · The paper itself

Abstract

The incorporation of fluorinated amino acids into proteins provides new opportunities to study biomolecular structure-function relationships in an elegant manner. The available strategies to incorporate the majority of fluorinated amino acids are not site-specific or imply important structural modifications. Here, we present a chemical biology approach for the site-specific incorporation of three commercially available C

Indexed as

Huntingtin ProteinProlineFluorineHalogenationHumansMolecular Dynamics SimulationFluorinefluoro-prolineHuntingtin ProteinProline

Identifiers

PMID39661394
PMCPMC11772113

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.