ArticleInvestigative ophthalmology & visual science2024
Epiretinal Membrane: Correlations Among Clinical, Immunohistochemical, and Biochemical Features and Their Prognostic Implications.
Article in Investigative ophthalmology & visual science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07095907 (Post-surgical Functional Results in Patients With Epiretinal Membrane Undergoing Controlled Macular Detachment), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Post-surgical Functional Results in Patients With Epiretinal Membrane Undergoing Controlled Macular Detachment: Pilot Study.
Who cites it
2 citing papers in PubMed.
- Immunohistochemical clinicopathologic correlation and OCT analysis of idiopathic and secondary epiretinal membrane specimens.International journal of ophthalmology · 2026Article
- Yes-Associated Protein (YAP) Is Associated With Disease Severity and Visual Prognosis in Epiretinal Membrane.Investigative ophthalmology & visual science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate correlations among clinical, immunohistochemical, and biochemical characteristics of epiretinal membranes (ERMs) and their prognostic implications. Methods: This prospective study included 120 patients with idiopathic ERM who underwent vitrectomy. Preoperative and postoperative best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) were measured. Surgical ERM tissues underwent immunohistochemistry (IHC) analysis, and vitreous samples were analyzed for cytokine levels. Statistical analysis assessed associations among BCVA, OCT metrics (ERM stage, inner-retinal irregularity index [IRII], ellipsoid zone disruption [EZD]), IHC features (cell density, protein expression), and cytokines. Results: The average age of the participants was 70.2 ± 7.6 years, and ERM stages were distributed as Stage 2 in 34 eyes (28.3%), Stage 3 in 54 eyes (45.0%), and Stage 4 in 32 eyes (26.7%). Advancing ERM stage was linked with worsening visual outcomes, higher preoperative IRII, increased EZD incidence, increased ERM cellularity, and elevated TGF-β1 level. Protein expression for myofibroblasts (αSMA), glial cells (GFAP), hyalocytes (CD45), and retinal pigment epithelium (RPE) cells (PRPH2) correlated positively with ERM stage. Multivariate analysis showed preoperative IRII significantly correlated with preoperative BCVA, GFAP, PRPH2, and type I collagen. TGF-β1 was significantly associated with preoperative IRII, αSMA, type I collagen, and N-cadherin, but not with postoperative BCVA. Postoperative BCVA was significantly correlated with preoperative BCVA, preoperative IRII, preoperative EZD, αSMA, and PRPH2. Conclusions: Early-stage ERM is associated with better visual prognosis, fewer inner and outer retinal changes in OCT, and fewer epithelial-mesenchymal transition-related alterations in ERM tissues. Key prognostic indicators for postoperative BCVA include preoperative BCVA, IRII, EZD, myofibroblasts, and RPE cells. TGF-β1 promotes the transdifferentiation of intraocular cells, impacting OCT features directly and visual outcomes indirectly.
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Registered trials
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