ArticleDrug delivery and translational research2025
Medicated and multifunctional composite alginate-collagen-hyaluronate based scaffolds prepared using two different crosslinking approaches show potential for healing of chronic wounds.
Article in Drug delivery and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- 3D Bioprinted Alginate-Gelatin-Collagen Based Hydrogels Laden With Fibroblast and Keratinocyte Cells Show Potential for Regeneration of Injured Skin.Macromolecular bioscience · 2026Article
- Development and Characterization of Collagen-Methylcellulose Sponge-like Matrices for Indomethacin Release in Wound Dressing Applications.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Recent Advances in Natural Polymers-based Hydrogels for Periodontal Regeneration.Macromolecular bioscience · 2026Review
- Revisiting applications of itaconic acid-based polymers obtained by (poly)condensation chemistry.Green chemistry : an international journal and green chemistry resource : GC · 2026Review
- Composite HPMC-Gelatin Films Loaded with Cameroonian and Manuka Honeys Show Antibacterial and Functional Wound Dressing Properties.Gels (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic wounds present significant challenges with high morbidity and mortality. A cost-effective dressing that can absorb large exudate volumes, is hemostatic and therapeutically active is of current interest. This study compares two crosslinking approaches on composite scaffolds comprising fish collagen (FCOL), hyaluronic acid (HA) and sodium alginate (SA) by respectively targeting HA and SA. Crosslinking involved reacting HA with polyethylene glycol diglycidyl ether (PEGDE)/itaconic acid (IT) (IPC scaffolds) or SA with calcium chloride (CC scaffolds) and the crosslinked gels (with/without BSA) freeze-dried. Selected optimized formulations were loaded with basic fibroblast growth factor (b-FGF) as medicated scaffold dressings. NMR and FTIR spectroscopies (crosslinking/component interactions), SEM (morphology), texture analysis (mechanical strength/adhesion), and exudate handling were used to characterize the physico-chemical properties of the scaffolds. Protein (BSA) release profiles, hemostasis, biocompatibility and wound closure were assessed using HPLC, whole blood and methyl thiazolyl tetrazolium (MTT) and scratch assays respectively. The CC SA:FCOL:HA scaffolds showed improved mechanical strength, porosity, water vapor transmission rate, retained structural integrity after absorbing 50% exudate and promoted cell proliferation. The IPC scaffolds showed enhanced structural integrity, excellent hemostasis, retained three times more exudate than non-crosslinked scaffolds and provided acceptable pore size for cell adhesion and proliferation. The results show potential of CC and IPC SA:FCOL:HA scaffolds as medicated dressings for delivering proteins to chronic wounds. The study's significance lies in their potential use as multifunctional, multi-targeted and therapeutic dressings to overcome challenges with chronic wounds and use as delivery platforms for other therapeutic agents for chronic wound healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.