ArticleDigestive diseases and sciences2025
Prevalence and Outcomes of Emergency Presentations of Colorectal Cancer in Veterans Affairs Health Care System.
Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Patterns of Colorectal Cancer Diagnosis in Older Adults: A SEER-Medicare Analysis of Health and Economic Impact of Missed Screening Opportunities.Journal of surgical oncology · 2026Article
- Emergency Diagnostic Phenotypes and Differential Survival in Colorectal Cancer: A Real-World Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Mortality after emergency presentation: evidence from a cohort of 929 378 Medicare beneficiaries with common cancers diagnosed 2008-2017.Journal of the National Cancer Institute · 2026Article
- Digital quality measure of potentially avoidable emergency presentations among patients with colorectal cancer.BMJ quality & safety · 2026Article
- Chronic military stress and glandular epithelial tumor biology: an integrative neuroendocrine-inflammatory framework with insights from microgravity gene discovery.Frontiers in oncology · 2026Article
- Geographic and Socioeconomic Disparities in Emergency Presentations Among Colorectal Cancer Patients in Victoria, Australia.Cancer medicine · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundColorectal cancer (CRC) diagnoses are frequently made through emergency presentations (EPs), a new cancer diagnosis following an emergency care episode or unplanned inpatient admission. The extent and implications of EPs are not well known in the Veterans Affairs (VA) health system, where robust CRC screening protocols exist. The impact of the COVID-19 pandemic on the route of CRC diagnosis also remains unclear.
methodsWe conducted a retrospective cohort study of all incident CRC cases diagnosed nationally in the VA health care system from 2017 to 2021. We applied a previously validated algorithm to identify CRC EPs and used multivariable logistic regression and Cox proportional hazards models to examine the associations between EPs and CRC stage, treatment, and mortality.
resultsWe identified 9,096 patients with CRC, 28.1% of whom had EPs, with the proportion of EPs increasing over the study period from 26.4% in 2017-2019 to 31.4% in 2020-2021. Patients with EPs were more likely to have advanced stage disease (adjusted OR 1.70; 95% CI 1.53-1.88) and less likely to receive cancer treatment (adjusted OR 0.65; 95% CI 0.56-0.75) than patients without EPs. Patients with EPs also had significantly higher mortality risk (adjusted HR 1.70; 95% CI 1.56-1.84).
conclusionIn a large cohort of patients diagnosed with CRC, we found EPs to be common and independently associated with worse cancer outcomes. EPs also increased during the COVID-19 pandemic. Interventions are needed to reduce potentially avoidable EPs and improve outcomes of patients with CRC diagnosis.
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