Evidence map›Paper›PMID 39661255›Full record

ArticleEuropean geriatric medicine2025

The gut microbiota genus Blautia is associated with skeletal muscle mass reduction in community-dwelling older Japanese adults: the Wakayama Study.

Masato Sakaguchi, Nobuyuki Miyai, Yan Zhang, Yukiko Sakamoto, Kazufumi Terada, Miyoko Utsumi, Tatsuya Takeshita, Mikio Arita

Abstract read
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Article in European geriatric medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Masato SakaguchiGraduate School of Health and Nursing Science, Wakayama Medical University, 580 Mikazura, P.O. Box 641-0011, Wakayama, Japan.
Nobuyuki MiyaiGraduate School of Health and Nursing Science, Wakayama Medical University, 580 Mikazura, P.O. Box 641-0011, Wakayama, Japan. miyain@wakayama-med.ac.jp.ORCID 0000-0002-7208-4405
Yan ZhangGraduate School of Health and Nursing Science, Wakayama Medical University, 580 Mikazura, P.O. Box 641-0011, Wakayama, Japan.
Yukiko SakamotoGraduate School of Health and Nursing Science, Wakayama Medical University, 580 Mikazura, P.O. Box 641-0011, Wakayama, Japan.
Kazufumi TeradaFaculty of Budo and Sport Studies, Tenri University, Nara, Japan.
Miyoko UtsumiWakayama Faculty of Nersing, Tokyo Healthcare University, Wakayama, Japan.
Tatsuya TakeshitaWakayama Occupational Health Support Center, Wakayama, Japan.
Mikio AritaDepartment of Cardiology, Sumiya Rehabilitation Hospital, Wakayama, Japan.

Funding

Japan Science and Technology Agency JPMJCE1302Japan Science and Technology Agency JPMJCE 2201Japan Science and Technology Agency JPMJPF2210Japan Society for the Promotion of Science (C) 16K09104Japan Society for the Promotion of Science (C) 17K01861Japan Society for the Promotion of Science (C)19K10581Japan Society for the Promotion of Science (C) 21K11116Japan Society for the Promotion of Science (C) 21K11703Japan Society for the Promotion of Science (C)25350894
6 · The paper itself

Abstract

purposeThis cross-sectional study examined the gut microbiota species associated with skeletal muscle mass reduction in a community-based sample of older Japanese adults.

methodsThe study included 744 participants (320 men and 424 women) aged 65-89 years (mean age: 73 years) with no history of treatment for colorectal, chronic kidney, or liver diseases. Bioelectrical impedance analysis was performed to estimate the appendicular skeletal muscle mass (ASM) of each participant. The gut microbiota composition was assessed using next-generation sequencing targeting the V3-V4 regions of the prokaryotic 16S rRNA genes. A self-administered questionnaire was used to evaluate daily living habits, including food intake associated with maintaining the gut microbiota.

resultsAmong the participants, those with reduced muscle mass (defined as an ASM index of less than 4.4 kg/m

conclusionElevated levels of the genus Blautia were associated with reduced skeletal muscle mass in older Japanese adults, suggesting that improving the gut microbiota may be a potential approach to preserving muscle mass among this population.

Indexed as

EubacterialesGastrointestinal MicrobiomeMuscle, SkeletalSarcopeniaAgedAged, 80 and overCross-Sectional StudiesEast Asian PeopleFemaleHumansIndependent LivingJapanMaleRNA, Ribosomal, 16SRNA, Ribosomal, 16SAlcohol consumptionGeneral populationGut microbiotaSarcopeniaSkeletal muscle massYogurt intake

Identifiers

PMID39661255

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.