Evidence map›Paper›PMID 39661064›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity.

Yan-Hong Cui, Jiangbo Wei, Hao Fan, Wenlong Li, Lijie Zhao, Emma Wilkinson, Jack Peterson, Lishi Xie, Zhongyu Zou, Seungwon Yang and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. A Novel Role of DELTEX2 in Maintaining Genomic Stability of Granulosa Cells During Ovarian Aging.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  5. Review
  6. Review
  7. FTO-modulated mJournal of translational medicine · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Regulation of RNA methylation linked to drug resistance in gastric cancer.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yan-Hong CuiDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-4169-6521
Jiangbo WeiDepartments of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637.
Hao FanDepartment of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL 60637.ORCID 0000-0001-5245-9698
Wenlong LiDepartments of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637.
Lijie ZhaoDepartments of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637.
Emma WilkinsonDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637.ORCID 0000-0003-3468-0326
Jack PetersonDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637.ORCID 0009-0006-6756-2800
Lishi XieDepartment of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL 60637.
Zhongyu ZouDepartments of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637.ORCID 0000-0001-7152-5435
Seungwon YangDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-8970-7373
Mark A ApplebaumDepartment of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637.ORCID 0000-0001-9766-8477
Justin KlineDepartment of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL 60637.
Jing ChenDepartment of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-5376-9062
Chuan HeDepartments of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637.
Yu-Ying HeDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-2665-7962

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI KUNLE ODUNSI · 1985 to 2026
$122.1M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Multi-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5M
Epitranscriptomic mechanism of environmental stress response and tumorigenesisR35ES031693 · NIEHS · UNIVERSITY OF CHICAGO · PI Yu-Ying He · 2023 to 2026
$4.2M
The mechanistic role of METTL14 in UVB-induced skin tumorigenesisR01ES030576 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, YU-YING · 2019 to 2023
$3.0M
FTO and RNA methylation in arsenic tumorigenicityR01ES031534 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, YU-YING · 2020 to 2022
$1.2M
Acquisition of a Q-Exactive HF Mass SpectrometerS10OD027016 · OD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI COLOGNA, STEPHANIE M · 2019 to 2019
$600k
HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) ES031693 ES031534 ES030576NCI NIH HHS P30 CA014599NCI NIH HHS T32 CA009594NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01 ES030576NIEHS NIH HHS R01 ES031534NIEHS NIH HHS R35 ES031693NIH HHS S10 OD027016
6 · The paper itself

Abstract

Here, we show that vitamin E succinate (VES) acts as a degrader for the m

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOUbiquitin-Protein LigasesAnimalsCell Line, TumorHumansImmunotherapyMiceMice, Inbred C57BLNeoplasmsProteolysisUbiquitinationAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanFTO protein, mouseUbiquitin-Protein LigasesDTX2FTOm6A RNA methylationubiquitin-mediated proteasomal degradationUFD1

Identifiers

PMID39661064
PMCPMC11665913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.