Evidence map›Paper›PMID 39661032›Full record

SynthesisInternational forum of allergy & rhinology2025

Ectopic olfactory neuroblastoma is associated with increased frequency of syndrome of inappropriate antidiuretic hormone secretion and reduced disease control: Case series with systematic review and pooled analysis.

Antonio Daloiso, Piergiorgio Gaudioso, Alessandro Vinciguerra, Mario Turri-Zanoni, Gabriele Testa, Diego Cazzador, Alessia Lambertoni, Alberto Daniele Arosio, Giacomo Contro, Stefano Taboni and 12 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Antonio DaloisoSection of Otorhinolaryngology-Head and Neck Surgery, Department of Neuroscience, University of Padova, Padova, Italy.ORCID 0000-0002-3687-8814
Piergiorgio GaudiosoSection of Otorhinolaryngology-Head and Neck Surgery, Department of Neuroscience, University of Padova, Padova, Italy.ORCID 0000-0001-6219-9180
Alessandro VinciguerraOtorhinolaryngology and Skull Base Center, AP-HP, Hospital Lariboisière, Paris, France.ORCID 0000-0003-4805-4908
Mario Turri-ZanoniDepartment of Otolaryngology-Head and Neck Surgery, ASST Lariana, Ospedale Sant'Anna, University of Insubria, Como, Italy.ORCID 0000-0002-3678-9088
Gabriele TestaUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Diego CazzadorUnit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale-Università Padova, Padova, Italy.ORCID 0000-0001-7272-7469
Alessia LambertoniDivision of Otolaryngology, Department of Biotechnology and LifeSciences, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.ORCID 0000-0002-2956-5895
Alberto Daniele ArosioDivision of Otolaryngology, Department of Biotechnology and LifeSciences, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.ORCID 0000-0002-8916-6562
Giacomo ControUnit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale-Università Padova, Padova, Italy.
Stefano TaboniUnit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale-Università Padova, Padova, Italy.ORCID 0000-0001-7084-8603
Vittorio RampinelliUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.ORCID 0000-0002-0901-6266
Cesare PiazzaUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.ORCID 0000-0002-2391-9357
Maurizio BignamiDivision of Otolaryngology, Department of Biotechnology and LifeSciences, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.
Enzo EmanuelliOtolaringology Unit, Ca' Foncello Hospital, Local Health Unit N.2 "Marca Trevigiana", Treviso, Italy.
Paolo BattagliaDepartment of Otolaryngology-Head and Neck Surgery, ASST Lariana, Ospedale Sant'Anna, University of Insubria, Como, Italy.
Paolo BossiMedical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.ORCID 0000-0003-0135-0224
Philippe HermanOtorhinolaryngology and Skull Base Center, AP-HP, Hospital Lariboisière, Paris, France.
Paolo CastelnuovoDivision of Otolaryngology, Department of Biotechnology and LifeSciences, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.ORCID 0000-0002-5184-6140
Ehab Y HannaDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0003-3241-2440
Piero NicolaiSection of Otorhinolaryngology-Head and Neck Surgery, Department of Neuroscience, University of Padova, Padova, Italy.ORCID 0000-0003-0443-3519
Davide MattavelliUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.ORCID 0000-0001-7023-6746
Marco FerrariSection of Otorhinolaryngology-Head and Neck Surgery, Department of Neuroscience, University of Padova, Padova, Italy.ORCID 0000-0002-4023-0121

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOlfactory neuroblastoma (ONB) is a rare malignant tumor originating from the olfactory neuroepithelium, typically within the sinonasal cavity. Cases of ONB originating outside of the olfactory cleft area are extremely rare and are referred to as "ectopic" (eONB), in contrast to "orthotopic" tumors (oONB). ONB has been associated with paraneoplastic syndromes (PNSs), including the syndrome of inappropriate antidiuretic hormone secretion (SIADH). This study investigate the association between eONB and SIADH and compared the prognosis of eONB to oONB.

methodsA systematic literature review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted, focusing on studies reporting eONB and oONB associated with SIADH. Data from four newly identified eONB cases were reported and a pooled analysis was performed. Statistical analyses were conducted to evaluate the prevalence of SIADH in eONB and oONB and to compare clinical outcomes in the two groups.

resultseONB had a significantly higher prevalence of SIADH (18.3%) compared to oONB (2.0%; p < 0.0001). Patients with eONB were younger, with a slight predominance of females. Recurrence-free survival and time-to-recurrence of eONB were worse than oONB, independently of other prognosticators.

conclusionseONB is associated with a significantly higher incidence of SIADH than oONB, suggesting distinct biological characteristics. Moreover, patients with eONB had worse prognostic outcomes. Further research is needed to understand the underlying mechanisms and improve management strategies for eONB.

Indexed as

Esthesioneuroblastoma, OlfactoryInappropriate ADH SyndromeNose NeoplasmsAgedFemaleHumansMaleMiddle AgedNasal CavityPrognosisesthesioneuroblastomaolfactory neuroblastomaparaneoplastic syndromeSchwartz–Bartter syndromesinonasal cancersinonasal tumorskull base cancerskull base tumorsyndrome of inappropriate antidiuretic hormone secretionvasopressin

Identifiers

PMID39661032
PMCPMC11697229

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.