Evidence map›Paper›PMID 39660954›Full record

ArticleProtein science : a publication of the Protein Society2025

Streptococcus pneumoniae GAPN is a key metabolic player necessary for host infection.

Eunjeong Lee, Anthony Saviola, Shaun Bevers, Jasmina S Redzic, Sean P Maroney, Steven Shaw, Emily Tamkin, Sam Fulte, Travis Nemkov, Nancy Meyer and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Streptococcus pneumoniae GAPN is a key metabolic player necessary for host infection.Protein science : a publication of the Protein Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eunjeong LeeDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Anthony SaviolaDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0001-6890-512X
Shaun BeversDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Jasmina S RedzicDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Sean P MaroneyDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Steven ShawDepartment of Otolaryngology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Emily TamkinDepartment of Otolaryngology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Sam FulteDepartment of Otolaryngology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Travis NemkovDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Nancy MeyerPacific Northwest Cryo-EM Center, Oregon Health and Science University, Portland, Oregon, USA.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Kirk C HansenDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Sarah E ClarkDepartment of Otolaryngology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Elan EisenmesserDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0002-6967-0892

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
UC San Diego RAPID Faculty Development Program in Infectious DiseasesR25AI147376 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ADRIANA H TREMOULET, Joann Trejo · 2020 to 2026
$2.5M
Airway Prevotella enhance innate immune-mediated protection against lung infectionR01AI172958 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Sarah E Clark · 2023 to 2026
$2.0M
The global regulation of dynamics and structure mediated by single hydride in a family of reductasesR01GM139892 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI EISENMESSER, ELAN Z · 2021 to 2024
$1.2M
Host factors influencing early clearance of Streptococcus pneumoniae from the middle ear following invasion from the nasopharynxR21DC019169 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI CLARK, SARAH E · 2022 to 2024
$583k
SARS-CoV-2 N interactions with RNA and host cell cyclophilin-AR21AI166292 · NIAID · UNIVERSITY OF COLORADO DENVER · PI EISENMESSER, ELAN Z · 2022 to 2023
$428k
Determining how the giant Streptococcus Pneumoniae IgA1 protease cleaves its host IgA1 substrate and how this interaction can be blockedR21AI146295 · NIAID · UNIVERSITY OF COLORADO DENVER · PI EISENMESSER, ELAN Z · 2020 to 2021
$428k
National Science Foundation 1807326NIAID NIH HHS R01 AI172958NIAID NIH HHS R21 AI146295NIAID NIH HHS R21 AI166292NIAID NIH HHS R25 AI147376NIDCD NIH HHS R21 DC019169NIGMS NIH HHS R01 GM139892NIGMS NIH HHS U24 GM129547NIH HHS R01 AI172958NIH HHS R01 GM139892NIH HHS R21 AI146295NIH HHS R21 DC019169NIH HHS U24GM129547
6 · The paper itself

Abstract

Streptococcus pneumoniae (S. pneumoniae) employs various metabolic pathways to generate nicotinamide adenine dinucleotide phosphate (NADPH), which is essential for redox balance, fatty acid synthesis, and energy production. GAPN, a non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, plays a role in this process by directly reducing NADP

Indexed as

Streptococcus pneumoniaeAnimalsBacterial ProteinsGlyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)HumansMiceOxidative StressPneumococcal InfectionsBacterial ProteinsGlyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)cryo‐EMGAPNglycolysismetabolismstructure

Identifiers

PMID39660954
PMCPMC11633051

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.