Evidence map›Paper›PMID 39660916›Full record

ReviewInfection and immunity2025

Prevalence and features of hypervirulent

Christi L McElheny, Alina Iovleva, Nathalie Chen, Dominic Woods, Akansha Pradhan, Jonah L Sonnabend, Aidan R Matunis, Nathan J Raabe, Janet S Lee, Giraldina Trevejo-Nuñez and 2 more

Abstract readReview
In one paragraph

Review in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Emergence of carbapenem-resistant putative hypervirulentEmerging microbes & infections · 2026
    Article
  3. The acquisition ofmBio · 2026
    Article
  4. Article
  5. The acquisition ofbioRxiv : the preprint server for biology · 2025
    Article
  6. Infection and immunity · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christi L McElhenyCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Alina IovlevaCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Nathalie ChenCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Dominic WoodsCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Akansha PradhanCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Jonah L SonnabendCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Aidan R MatunisCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Nathan J RaabeCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Janet S LeeDivision of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-6812-6043
Giraldina Trevejo-NuñezCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Daria Van TyneCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7284-0103
Yohei DoiCenter for Innovative Antimicrobial Therapy, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-9620-2525

Funding

Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCVERRY, BRYAN J · 2014 to 2023
$21.3M
Institutional Career Development CoreKL2TR001856 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, KRISTIN N, RUBIO, DORIS M · 2016 to 2025
$13.8M
Mechanisms of host protection against pathogen-secreted proteases in acute lung injuryR01HL136143 · NHLBI · WASHINGTON UNIVERSITY · PI LEE, JANET SOJUNG · 2017 to 2024
$4.4M
Colistin-resistant Acinetobacter baumanniiR01AI104895 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI, ERNST, ROBERT K · 2014 to 2024
$4.2M
The role of ACOD1 in immunomodulation in intrapulmonary Klebsiella pneumoniae infectionR01HL142084 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, KONG · 2018 to 2021
$2.4M
Spatiotemporal control of early matricellular events in the injured lungR01HL177904 · NHLBI · WASHINGTON UNIVERSITY · PI Jaehyung Cho, Janet Sojung Lee · 2025 to 2026
$1.5M
University of Pittsburgh Training Program in Antimicrobial ResistanceT32AI138954 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 2019 to 2023
$971k
Negative regulation of inflammation during Klebsiella pneumoniae infectionR21AI153549 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREVEJO-NUNEZ, GIRALDINA · 2021 to 2022
$433k
NCATS NIH HHS KL2 TR001856NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R01 HL136143NHLBI NIH HHS R01 HL142084NHLBI NIH HHS R01 HL177904NIAID NIH HHS R01 AI104895NIAID NIH HHS R21 AI153549NIAID NIH HHS T32 AI138954
6 · The paper itself

Abstract

Hypervirulent

Indexed as

Klebsiella InfectionsKlebsiella pneumoniaeAgedAnimalsBacterial ProteinsDisease Models, AnimalFemaleHospitalsHumansMaleMiceMiddle AgedPennsylvaniaPrevalenceProspective StudiesUnited StatesBacterial ProteinsVirulence FactorshypervirulenceKlebsiellasurveillance

Identifiers

PMID39660916
PMCPMC11784238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.