Evidence map›Paper›PMID 39660897›Full record

ArticleInfection and immunity2025

Polycytotoxic T cells mediate antimicrobial activity against intracellular

Marc Zumwinkel, Aaron Chirambo, Markus Zähnle, Max Bürger, Mark Grieshober, Vincent Romahn, Henry Mwandumba, Steffen Stenger

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Bystander CD8Frontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marc ZumwinkelInstitute for Medical Microbiology and Hygiene, University Hospital Ulm, Ulm, Germany.ORCID 0009-0001-5402-7300
Aaron ChiramboMalawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Markus ZähnleInstitute for Medical Microbiology and Hygiene, University Hospital Ulm, Ulm, Germany.
Max BürgerInstitute for Medical Microbiology and Hygiene, University Hospital Ulm, Ulm, Germany.
Mark GrieshoberInstitute for Medical Microbiology and Hygiene, University Hospital Ulm, Ulm, Germany.
Vincent RomahnInstitute for Medical Microbiology and Hygiene, University Hospital Ulm, Ulm, Germany.
Henry MwandumbaMalawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Steffen StengerInstitute for Medical Microbiology and Hygiene, University Hospital Ulm, Ulm, Germany.ORCID 0000-0001-5471-0807

Funding

Deutsche Forschungsgemeinschaft (DFG) 316249678Deutsche Forschungsgemeinschaft (DFG) 425963938EC | ERC | HORIZON EUROPE European Research Council (ERC) 101080309-2
6 · The paper itself

Abstract

Protection against infections with intracellular bacteria requires the interaction of macrophages and T-lymphocytes, including CD8

Indexed as

CD8-Positive T-LymphocytesMacrophagesMycobacterium tuberculosisT-Lymphocytes, CytotoxicTuberculosisCytokinesGranzymesHumansNK Cell Lectin-Like Receptor Subfamily CCytokinesGranzymesKLRC1 protein, humanNK Cell Lectin-Like Receptor Subfamily Cantimicrobial activityCD8+ T lymphocytesNKG2ANKG2Cpolycytotoxictuberculosis

Identifiers

PMID39660897
PMCPMC11784352

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.