Evidence map›Paper›PMID 39660885›Full record

ArticleJournal of bacteriology2025

Lipid a remodeling modulates outer membrane vesicle biogenesis by

Sarah R Alaei, Alisa J King, Karim Banani, Angel Reddy, Joshua Ortiz, Alexa L Knight, Jessica Haldeman, Thet Hnin Su, Hana Park, Stephen R Coats and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Infection and immunity · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Outer membrane vesicles ofFrontiers in microbiology · 2025
    Review
  9. Recognition ofJournal of oral microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sarah R AlaeiDivision of Science and Mathematics, School of Interdisciplinary Arts and Sciences, University of Washington, Tacoma, Washington, USA.ORCID 0009-0007-3928-0336
Alisa J KingDivision of Science and Mathematics, School of Interdisciplinary Arts and Sciences, University of Washington, Tacoma, Washington, USA.
Karim BananiDepartment of Periodontics, School of Dentistry, University of Washington, Seattle, Washington, USA.
Angel ReddyDivision of Science and Mathematics, School of Interdisciplinary Arts and Sciences, University of Washington, Tacoma, Washington, USA.
Joshua OrtizDivision of Science and Mathematics, School of Interdisciplinary Arts and Sciences, University of Washington, Tacoma, Washington, USA.
Alexa L KnightDivision of Science and Mathematics, School of Interdisciplinary Arts and Sciences, University of Washington, Tacoma, Washington, USA.
Jessica HaldemanDivision of Science and Mathematics, School of Interdisciplinary Arts and Sciences, University of Washington, Tacoma, Washington, USA.
Thet Hnin SuDepartment of Periodontics, School of Dentistry, University of Washington, Seattle, Washington, USA.
Hana ParkDepartment of Periodontics, School of Dentistry, University of Washington, Seattle, Washington, USA.
Stephen R CoatsDepartment of Periodontics, School of Dentistry, University of Washington, Seattle, Washington, USA.
Sumita JainDepartment of Periodontics, School of Dentistry, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-1791-0089

Funding

Regulation and impact of lipid A modification in the pathogenesis of Porphyromonas gingivalisR01DE032027 · NIDCR · UNIVERSITY OF WASHINGTON · PI JAIN, SUMITA · 2022 to 2024
$1.1M
Characterization of the effect of a newly identified gene encoding the lipid A deacylase on Porphyromonas gingivalis virulenceR21DE028756 · NIDCR · UNIVERSITY OF WASHINGTON · PI DARVEAU, RICHARD PETERS, JAIN, SUMITA · 2019 to 2020
$428k
HHS | National Institutes of Health (NIH) 5R01DE032027NIDCR NIH HHS R01 DE032027NIDCR NIH HHS R21 DE028756University of Washington (UW) Elam M. and Georgina E. Hack Memorial Research FundUniversity of Washington (UW) Founders EndowmentUniversity of Washington (UW) Research Startup Funds
6 · The paper itself

Abstract

Outer membrane vesicles (OMVs) are small membrane enclosed sacs released from bacteria which serve as carriers of biomolecules that shape interactions with the surrounding environment. The periodontal pathogen,

Indexed as

Bacterial Outer MembraneLipid APorphyromonas gingivalisBacterial ProteinsBiofilmsToll-Like Receptor 4Bacterial ProteinsLipid AToll-Like Receptor 4lipid Aouter membrane vesiclesPorphyromonas gingivalis

Identifiers

PMID39660885
PMCPMC11784228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.