ArticleClinical and experimental immunology2025
A study of changes in hematologic parameters in patients with migraine.
Article in Clinical and experimental immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Association Between Peripheral Inflammation Biomarkers and Clinical Phenotypes in Patients With Medication Overuse Headache: A Cross-sectional Study.Brain and behavior · 2025Article
- Volumetric analysis of hippocampal subregions in migraine without aura: an exploratory study on mechanisms underlying migraine chronification.The journal of headache and pain · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
introductionTo evaluate the characteristics of hematological parameters and peripheral inflammatory markers (PIMs) in migraine, including chronic migraine (CM) and episodic migraine (EM), and to explore their underlying mechanisms.
methodA total of 88 subjects were enrolled, 58 with migraine (28 with CM and 30 with EM) and 30 healthy controls. All subjects were matched for age, gender, and body mass index, and peripheral blood was collected. Hematological parameters and PIMs were compared between migraineurs and healthy controls. The patients underwent hematological laboratory testing and calculated the PIMs. PIMs included neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio (LMR), neutrophil/monocyte ratio, platelet/lymphocyte ratio, and platelet/monocyte ratio (PMR) ratio.
resultMonocyte counts in migraine patients were significantly lower compared with healthy controls, while LMR and PMR were significantly higher. Statistically significant differences were observed in monocyte counts, LMR, and PMR among the three groups of CM, EM, and HC patients. Post hoc Bonferroni t-test showed that monocyte counts were significantly lower in the EM group compared with the HC group, while LMR and PMR were significantly higher. Comparison between the EM and CM groups showed that LMR was significantly higher in the EM group. Differences in monocyte counts, LMR, and PMR between the CM and HC groups were not statistically significant. Receiver operating characteristic curve analysis indicated that the area under the curve (AUC) for the diagnosing migraine using the combination of Mon, LMR, and PMR was 0.707, and the AUC for the diagnosis of EM was 0.758. The AUC value of PMR for diagnosing CM was 0.669, while the AUC for the combination of LMR and platelet/lymphocyte ratio in distinguishing CM and EM was 0.705.
conclusionOur findings indicate that migraine and its subtypes exhibit abnormalities in monocyte counts and PIMs, which possess diagnostic predictive value for differentiating migraine and its subtypes. This suggests that systemic inflammation may play a role in the pathogenesis of migraine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.