ArticleThe British journal of psychiatry : the journal of mental science2024
Transient patterns of advanced brain ageing in female adolescents with anorexia nervosa.
Article in The British journal of psychiatry : the journal of mental science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Genetically informed dissection of multimodal brain aging and ten major psychiatric disorders.Molecular psychiatry · 2026Article
- A Maturation-Aware Machine Learning Framework for Screening the Nutritional Status of Adolescents.Nutrients · 2026Article
- Potential vulnerability and resilience to accelerated brain aging in women exposed to stressful life events: insights from the brain age prediction model.Neurobiology of stress · 2025Article
- Does restrictive anorexia nervosa impact brain aging? A machine learning approach to estimate age based on brain structure.Computers in biology and medicine · 2025Article
- Mapping the Mind: Gray Matter Signatures of Personality Pathology in Female Adolescent Anorexia Nervosa Persist Through Treatment.Journal of clinical medicine · 2025Article
- Shaping the Future of Psychiatric Neurosurgery: From Connectomic Precision to Technological Integration.Brain sciences · 2025Review
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Authors and funding
7 authors.
Funding
Abstract
backgroundAnorexia nervosa is a psychiatric disorder characterised by undernutrition, significantly low body weight and large, although possibly transient, reductions in brain structure. Advanced brain ageing tracks accelerated age-related changes in brain morphology that have been linked to psychopathology and adverse clinical outcomes.
aimThe aim of the current case-control study was to characterise cross-sectional and longitudinal patterns of advanced brain age in acute anorexia nervosa and during the recovery process.
methodMeasures of grey- and white-matter-based brain age were obtained from T1-weighted magnetic resonance imaging scans of 129 acutely underweight female anorexia nervosa patients (of which 95 were assessed both at baseline and after approximately 3 months of nutritional therapy), 39 recovered patients and 167 healthy female controls, aged 12-23 years. The difference between chronological age and grey- or white-matter-based brain age was calculated to indicate brain-predicted age difference (BrainAGE
resultsAcute anorexia nervosa patients at baseline, but not recovered patients, showed a higher BrainAGE
conclusionsOur findings suggest that in patients with anorexia nervosa, undernutrition is an important predictor of advanced grey-matter-based brain age, which itself might be transient in nature and largely undetectable after weight recovery.
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