Evidence map›Paper›PMID 39660785›Full record

ArticleCancer2025

The 2021 US Preventive Services Task Force lung cancer screening eligibility criteria disproportionately exclude younger Black patients with lung cancer.

Alexandra L Potter, Sangkavi Kuhan, Priyanka Senthil, Arian Mansur, Chinmay Haridas, Deepti Srinivasan, Arvind Kumar, Wei Zheng, Erica T Warner, Chi-Fu Jeffrey Yang

Abstract read
In one paragraph

Article in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexandra L PotterDivision of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Sangkavi KuhanDivision of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-8673-7449
Priyanka SenthilDivision of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Arian MansurDivision of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Chinmay HaridasDivision of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Deepti SrinivasanDivision of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Arvind KumarDepartment of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Nashville, Tennessee, USA.
Erica T WarnerClinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-2671-0313
Chi-Fu Jeffrey YangDivision of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Southern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0M
NCI NIH HHS P30 CA068485NCI NIH HHS U01 CA202979NCI NIH HHS U01CA202979
6 · The paper itself

Abstract

backgroundThe 2021 US Preventive Services Task Force (USPSTF) lung cancer screening guideline may continue to exclude many younger Black individuals who have not yet accumulated enough smoking pack-years to be eligible for screening. The objective of this study was to evaluate the proportions of Black and White patients with lung cancer, stratified by age at diagnosis, who would have been eligible for lung cancer screening.

methodsIncident lung cancer cases among Black and White individuals aged 50-80 years with a smoking history in the Southern Community Cohort Study (SCCS) were identified for analysis. The proportions of Black and White individuals, stratified by age at diagnosis, who would have qualified for screening under the 2013 and 2021 USPSTF guidelines were calculated.

resultsA total of 1856 individuals met inclusion criteria. Compared to the 2013 USPSTF guideline, the 2021 USPSTF guideline significantly increased the proportions of Black and White patients with lung cancer who would have qualified for screening in all age groups evaluated. However, under the 2021 USPSTF guideline, there remained a notable racial disparity in lung cancer screening eligibility, particularly among younger patients with lung cancer. Only 47.4% and 61.9% of Black patients aged 50-54 and 50-59 years, respectively, would have qualified for screening under the 2021 USPSTF guideline compared to 80.3% and 88.8% of White patients aged 50-54 and 50-59 years, respectively. With increasing age, the racial disparity in lung cancer screening eligibility between Black and White patients with lung cancer was reduced, and there were no longer any statistically significant differences in screening eligibility between Black and White patients with lung cancer aged 70-74 and 75-80 years. Of Black individuals aged 50-54 and 55-59 years who were ineligible for screening, 100% and 97.5% were ineligible because they had smoked fewer than 20 pack-years, respectively.

conclusionsThis analysis of SCCS participants with lung cancer found that the 2021 USPSTF eligibility criteria disproportionately exclude many younger Black individuals with lung cancer, primarily because they have too few smoking pack-years.

Indexed as

Black or African AmericanEarly Detection of CancerLung NeoplasmsAdvisory CommitteesAgedAged, 80 and overAge FactorsCohort StudiesFemaleHumansMaleMass ScreeningMiddle AgedSmokingUnited StatesWhiteearly detectionlung cancerlung cancer screening eligibilitypack‐yearsracial disparities

Identifiers

PMID39660785
PMCPMC11925556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.