Evidence map›Paper›PMID 39660526›Full record

ArticleCurrent pharmaceutical biotechnology2025

Cardioprotective Efficacy of Quercetin against Cardiotoxicity Induced by Different Diameters of Sphere Gold Nanoparticles (GNPs).

Wael A M Ghonimi, Foll Alnada A F Abdelrahman, Fawiziah K Alharbi, Maha Alsunbul, Fawziah A Al-Salmi, Doaa Abdelrahaman, Eman Fayad, Shafika A El Sayed

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Article in Current pharmaceutical biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Wael A M GhonimiDepartment of Histology and Cytology, Faculty of Veterinary Medicine, Zagazig University, 44519 Zagazig, Egypt.ORCID 0000-0003-1324-0655
Foll Alnada A F AbdelrahmanDepartment of Histology and Cytology, Faculty of Veterinary Medicine, Zagazig University, 44519 Zagazig, Egypt.
Fawiziah K AlharbiDepartment of Biology, College of Science, Buraydah, Qassim University, Buraydah, Saudi Arabia.
Maha AlsunbulDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
Fawziah A Al-SalmiBiology Department, College of Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Doaa AbdelrahamanInternal Medicine Department, Princess Nourah bint Abdulrahman University, 84428/11671, Riyadh, Saudi Arabia.
Eman FayadDepartment of Biotechnology, College of Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Shafika A El SayedDepartment of Histology and Cytology, Faculty of Veterinary Medicine, Zagazig University, 44519 Zagazig, Egypt.

Funding

Deanship of Graduate Studies and Scientific Research, Qassim University, Saudi Arabia QU-APC-2025Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia PNURSP2024R736
6 · The paper itself

Abstract

backgroundGold nanoparticles (GNPs) have garnered significant attention in the biomedicine field due to their exceptional electrical, mechanical, chemical, and optical characteristics. The interaction of these remarkable potentials with biological tissues carries a risk of toxicity. Quercetin (Qur) is a natural flavonoid and exhibits numerous pharmacological impacts, especially anti-inflammatory, anti-apoptotic, and antioxidant.

objectivesThis investigation aimed to clarify the potential cardiotoxicity induced by different diameters of spherical GNPs as well as to evaluate the possible cardioprotective roles of Qur against the most toxic diameter of GNPs.

methodsRats were randomly grouped and treated with or without sphere GNPs (10, 20 and 50 nm) and Qur (200 mg/kg b.wt.). Heart and blood samples were collected and subjected to histological, immunohistochemical and biochemical investigations.

resultsWhen compared to the groups treated with 20 and 50 nm, the 10 nm GNPs dramatically increased the levels of cardiac biomarkers, including Troponin I, Creatine kinase isoenzyme-MB (CK-MB), CK-Total, lactate dehydrogenase (LDH).

conclusionThe size of GNPs is crucial to their toxicological impact on cardiac tissues where 10 nm GNPs can induce severe histological damage, potent cytotoxicity, and apoptosis rather than larger particles. Otherwise, pre-co-treatment with Qur revealed a significant cardioprotective effect against GNPs cardiotoxicity.

Indexed as

Cardiotonic AgentsCardiotoxicityGoldMetal NanoparticlesQuercetinAnimalsAntioxidantsApoptosisMaleMyocardiumMyocytes, CardiacParticle SizeRatsRats, WistarAntioxidantsCardiotonic AgentsGoldQuercetincardioprotectivecardiotoxicityGold nanoparticleshistopathologynatural flavonoid.quercetin

Identifiers

PMID39660526

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.