Trial reportClinical and translational science2024
Efficacy and safety of 4-hydroxy 2-methyl-N-(5-methyl-2-thiazolyl)-2H-1, 2-benzothiazin-3-carboxamide 1,1-dioxide, a fast-acting meloxicam formulation, on moderate-to-severe pain following abdominal surgery: A phase III randomized controlled trial.
Trial report in Clinical and translational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
30 authors.
Xiaohua LiuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0005-7409-6695
Yanhua ZhaoDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0002-6553-9755
Mengchang YangDepartment of Anesthesiology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, China.ORCID 0000-0002-6813-4174
Jinghua RenDepartment of Anesthesiology, The Second People's Hospital of Yibin, Yibin, China.ORCID 0009-0009-4137-0191
Wen OuyangDepartment of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China.ORCID 0009-0002-3426-3848
Saiying WangDepartment of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China.ORCID 0000-0003-0083-5764
Yufei ShenDepartment of Gynaecology, Nanjing Women and Children's Healthcare Hospital, Nanjing, China.ORCID 0009-0007-0932-5361
Yuanli GaoDepartment of Anesthesiology, Maanshan People's Hospital, Maanshan, China.ORCID 0009-0006-7922-6361
Ling ZhaoDepartment of Anesthesiology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, China.ORCID 0009-0001-7226-0923
Zhong QinDepartment of Anesthesiology, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi, China.ORCID 0009-0003-1967-7732
Jun CaoDepartment of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0001-7563-7071
Diansan SuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-9755-1025
Weifeng YuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-6408-2338
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
4-hydroxy 2-methyl-N-(5-methyl-2-thiazolyl)-2H-1, 2-benzothiazin-3-carboxamide 1,1-dioxide (QP001), a novel long-lasting meloxicam formulation, may provide adequate postoperative pain relief with a good safety profile. This study aimed to evaluate the efficacy and safety of QP001 for moderate-to-severe pain following abdominal surgery. This multicenter, randomized, double-blind, placebo-controlled phase III trial recruited patients undergoing abdominal surgery at 23 centers between October 30, 2022, and July 10, 2023. Patients were randomized to a QP001 or placebo group in a 2:1 ratio. Postoperative pain intensity was evaluated using the Numerical Rating Scale. The primary efficacy outcome was the area under curve (AUC) of pain intensity-time 0-24 h after awakening from anesthesia (AUC
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Efficacy and safety of 4-hydroxy 2-methyl-N-(5-methyl-2-thiazolyl)-2H-1, 2-benzothiazin-3-carboxamide 1,1-dioxide, a fast-acting meloxicam formulation, on moderate-to-severe pain following abdominal surgery: A phase III randomized controlled trial. · full record | OpenQuestion