ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2024
Association and Diagnostic Value of TyG-BMI for Hyperuricemia in Patients with Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between the triglyceride-glucose index and serum uric acid: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Association between TyHGB and hyperuricemia and gout in patients with type-2 diabetes mellitus.BMC endocrine disorders · 2026Article
- Association between the combination of the triglyceride-glucose index and obesity-related indices with hyperuricemia among children and adolescents in China.Lipids in health and disease · 2025Article
- Development and validation of a non-invasive prediction model for identifying high-risk children with metabolic dysfunction-associated fatty liver disease.Frontiers in pediatrics · 2025Article
- The triglyceride glucose-body mass index is positively associated with higher risk of hypertension in rural southwest Chinese population: a cross sectional study.Frontiers in cardiovascular medicine · 2025Article
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7 authors.
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Abstract
Purpose: This study aimed to investigate the association between TyG-BMI and hyperuricemia in NAFLD patients and assess its potential diagnostic value compared to the TyG index. Patients and Methods: This study selected the patients diagnosed with fatty liver disease at the Affiliated Hospital of Chengde Medical University between September and December 2023. These patients were divided into NAFLD without HUA (NAFLD-NUA, n=1166) and NAFLD with HUA (NAFLD-HUA, n=844) groups. Baseline characteristics between the groups were compared. Patients were divided into quartiles (Q1-Q4) according to their TyG-BMI level; the lowest quartile (Q1) was used as the reference group. Multivariate logistic regression analysis was used to investigate the association between TyG-BMI and HUA. Receiver operating characteristics curve analysis and area under the curve (AUC) were used to evaluate the diagnostic accuracy. Results: Patients in the NAFLD-HUA group had higher levels of TyG-BMI than patients in the NAFLD-NUA group(252.45±34.11VS 234.34±31.88, P<0.001). Pearson correlation analysis showed that TyG-BMI levels were positively correlated with serum uric acid (SUA) (r=0.309, P<0.001). After adjusting for potential confounders, logistic regression analysis revealed that TyG-BMI was a risk factor for HUA(OR:1.019 95% CI:(1.012, 1.027).) and shows superior diagnostic accuracy (AUC: 0.656) compared to the TyG index (AUC: 0.605). Conclusion: TyG-BMI index is a risk factor for HUA in patients with NAFLD, and demonstrates acceptable diagnostic accuracy for NAFLD-HUA. But further prospective studies are needed to confirm these findings.
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