Evidence map›Paper›PMID 39660107›Full record

ArticleRheumatology advances in practice2024

Similarities and differences in self-reported symptoms and comorbidities between hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders.

Ashley A Darakjian, Mira Bhutani, DeLisa Fairweather, S Christian Kocsis, Jessica J Fliess, Sami Khatib, Gabe J Weigel, Elizabeth J McCabe, Varsini Balamurugan, Evan E Perona and 16 more

Abstract read
In one paragraph

Article in Rheumatology advances in practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Connective tissue and genetics in the pathogenesis of rectal prolapse: A scoping review.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Article
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  9. [Hypermobility-Importance in rheumatology].Zeitschrift fur Rheumatologie · 2025
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Ashley A DarakjianDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0009-0001-1913-9200
Mira BhutaniDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
DeLisa FairweatherDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0003-3093-1810
S Christian KocsisDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
Jessica J FliessDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0009-0004-7689-3172
Sami KhatibDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
Gabe J WeigelDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0009-0009-7410-923X
Elizabeth J McCabeDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0001-6711-4051
Varsini BalamuruganDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
Evan E PeronaDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
Jessica M GehinDepartment of General Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0003-4757-416X
Emily R WhelanDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
Angita JainDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.
Hanna SledgeDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA.
David O HodgeDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA.
Todd D RozenDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0002-1404-9919
Francis A FarrayeDivision of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0001-6371-2441
Ozan SoyerDepartment of General Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.
Joseph CheungDivision of Allergy, Pulmonary and Sleep Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0002-1222-7603
Stephanie L GrachDepartment of General Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0002-8337-6219
David ShireyPhysical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
Shilpa GajarawalaDepartment of General Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0002-8891-6157
Bala MunipalliDepartment of General Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0002-1188-5495
Chrisandra L ShufeltDepartment of General Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0001-6886-9210
Dacre R T KnightDepartment of General Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0001-6206-0680
Katelyn A BrunoDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0001-8980-6059

Funding

Role of mitochondrial extracellular vesicles in CVB3 myocarditis by sexR01HL164520 · NHLBI · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2022 to 2025
$3.0M
Role of viral mitophagosomes in driving sex differences in myocarditisR21AI145356 · NIAID · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA, SIN, JON · 2019 to 2020
$463k
Adipose-derived biogenic nanoparticles for treatment of myocarditis/DCM(MPDPI)R21AI152318 · NIAID · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA, WOLFRAM, JOY · 2020 to 2021
$430k
Vitamin D Binding Protein (DBP) in Innate Immune Cell Response in Viral MyocarditisR21AI163302 · NIAID · UNIVERSITY OF FLORIDA · PI BRUNO, KATELYN ANN · 2021 to 2022
$430k
Elucidating the innate and adaptive immune mechanism differences during viral myocarditis between pediatric and adult populations: role of sex, age and hormone statusR21AI180863 · NIAID · UNIVERSITY OF FLORIDA · PI BRUNO, KATELYN ANN · 2024 to 2025
$413k
Sex differences in exercise-induced mitochondrial function during viral myocarditisR21AI154927 · NIAID · MAYO CLINIC JACKSONVILLE · PI FAIRWEATHER, DELISA · 2020 to 2021
$403k
American Heart Association-American Stroke Association 23SCEFIA1153413NHLBI NIH HHS R01 HL164520NIAID NIH HHS R21 AI145356NIAID NIH HHS R21 AI152318NIAID NIH HHS R21 AI154927NIAID NIH HHS R21 AI163302NIAID NIH HHS R21 AI180863
6 · The paper itself

Abstract

Objectives: Patients with hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) experience a wide array of symptoms and system disorders. This study aimed to identify whether differences occurred in 115 self-reported symptoms and comorbidities in patients diagnosed with hEDS or HSD. Methods: In this study we analysed self-reported data from an EDS Clinic intake questionnaire in patients diagnosed with hEDS, HSD or no hypermobile conditions. Results: From 1 November 2019 to 7 March 2024, the EDS Clinic saw 2088 patients. Using the 2017 diagnostic criteria, 66.5% were diagnosed with HSD ( Conclusion: Although we found an overlap in some symptoms and comorbidities self-reported by hEDS/HSD patients, such as allergy/atopy, headache/migraine and gastrointestinal symptoms, our findings suggest key differences exist between the two diagnoses, suggesting that hEDS and HSD may be distinct conditions.

Indexed as

allergycomorbiditiesheadachehypermobile Ehlers–Danlos syndromehypermobility spectrum disordersmigrainepain

Identifiers

PMID39660107
PMCPMC11630848

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.