Evidence map›Paper›PMID 39660065›Full record

ArticlePNAS nexus2024

Molecular dynamics and machine learning stratify motion-dependent activity profiles of S-layer destabilizing nanobodies.

Adam J Cecil, Adrià Sogues, Mukund Gurumurthi, Kaylee S Lane, Han Remaut, Alexander J Pak

Abstract read
In one paragraph

Article in PNAS nexus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Collective fluctuations underlying nanobody inhibitory activity targetingbioRxiv : the preprint server for biology · 2026
    Article
  2. Nanobodies in animal infectious disease control: diagnosis and therapy.Frontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adam J CecilDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO 80401, USA.ORCID https://orcid.org/0000-0002-7596-0845
Adrià SoguesStructural and Molecular Microbiology, VIB-VUB Center for Structural Biology, Pleinlaan 2, 1050 Brussels, Belgium.ORCID https://orcid.org/0000-0002-5752-6009
Mukund GurumurthiQuantitative Biosciences and Engineering Program, Colorado School of Mines, Golden, CO 80401, USA.
Kaylee S LaneComputer Science and Software Engineering, Rose-Hulman Institute of Technology, Terre Haute, IN 47803, USA.ORCID https://orcid.org/0009-0000-9546-2280
Han RemautStructural and Molecular Microbiology, VIB-VUB Center for Structural Biology, Pleinlaan 2, 1050 Brussels, Belgium.ORCID https://orcid.org/0000-0002-9775-4102
Alexander J PakDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO 80401, USA.ORCID https://orcid.org/0000-0003-2823-6480

Funding

Multiscale Modeling of B. Anthracis Surface Layer Assembly and Depolymerization by NanobodiesR21AI168838 · NIAID · COLORADO SCHOOL OF MINES · PI PAK, ALEXANDER · 2022 to 2023
$393k
NIAID NIH HHS R21 AI168838
6 · The paper itself

Abstract

Nanobody (Nb)-induced disassembly of surface array protein (Sap) S-layers, a two-dimensional paracrystalline protein lattice from

Identifiers

PMID39660065
PMCPMC11631148

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.