Evidence map›Paper›PMID 39659941›Full record

ArticleAmerican journal of cancer research2024

The effect of body mass index at diagnosis on survival of patients with squamous cell head and neck carcinoma.

Roberta Pastorino, Denise Pires Marafon, Nicolò Lentini, Ilda Hoxhaj, Adriano Grossi, Luca Giraldi, Antonella Rondinò, Gabriella Cadoni, Jerry Polesel, Diego Serraino and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Roberta PastorinoSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore Rome, Italy.
Denise Pires MarafonSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore Rome, Italy.
Nicolò LentiniSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore Rome, Italy.
Ilda HoxhajSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore Rome, Italy.
Adriano GrossiSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore Rome, Italy.
Luca GiraldiSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore Rome, Italy.
Antonella RondinòSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore Rome, Italy.
Gabriella CadoniDipartimento Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, Fondazione Policlinico Universitario A. Gemelli IRCCS Rome, Italy.
Jerry PoleselUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS Aviano, Italy.
Diego SerrainoUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS Aviano, Italy.
Carlo La VecchiaDepartment of Clinical Sciences and Community Health, University of Milan Milan, Italy.
Werner GaravelloDepartment of Otorhinolaryngology, School of Medicine and Surgery, University of Milano-Bicocca Milan, Italy.
Cristina CanovaUniversity of Padua Padova, Italy.
Lorenzo RichiardiDepartment of Medical Sciences, University of Turin and CPO-Piemonte Turin, Italy.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology Warsaw, Poland.
Tamas PandicsNational Public Health Center Budapest, Hungary.
Tom DuddingBristol Dental School, University of Bristol Bristol, UK.
Andy NessBristol Dental School, University of Bristol Bristol, UK.
Steve ThomasBristol Dental School, University of Bristol Bristol, UK.
Miranda PringBristol Dental School, University of Bristol Bristol, UK.
Karl KelseyBrown University Providence, RI, USA.
Michael McCleanBoston University School of Public Health Boston, MA, USA.
Patrick BradshawDivision of Epidemiology, School of Public Health, University of California Berkeley, CA, USA.
Zuo-Feng ZhangUCLA School of Public Health Los Angeles, CA, USA.
Hal MorgensternDepartment of Epidemiology and Environmental Health Sciences, School of Public Health, University of Michigan Ann Arbor, MI, USA.
Laura RozekEnvironmental Health Sciences, University of Michigan Ann Arbor, MI, USA.
Gregory WolfDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Ann Arbor, MI, USA.
Andrew OlshanUniversity of North Carolina School of Public Health Chapel Hill, NC, USA.
Geoffrey LiuPrincess Margaret Hospital University Health Network Toronto, Canada.
Rayjean HungLunenfeld-Tanenbaum Research Institute, Sinai Health and University of Toronto Toronto, Canada.
Marta VilenskyInstitute of Oncology Angel H. Roffo, University of Buenos Aires Buenos Aires, Argentina.
Marcos Brasilino de CarvalhoDepartment of Head and Neck, Heliopolis Hospital São Paulo, Brazil.
Rossana Verónica Mendonza LópezCancer Institute of The State of São Paulo (ICESP) São Paulo, Brazil.
Victor Wunsch-FilhoFundação Oncocentro de São Paulo (FOSP) São Paulo, Brazil.
Paolo BoffettaDepartment of Medical and Surgical Sciences, University of Bologna Bologna, Italy.
Mia HashibeDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine and Huntsman Cancer Institute Salt Lake City, UT, USA.
Yuan-Chin Amy LeeDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine and Huntsman Cancer Institute Salt Lake City, UT, USA.
Stefania BocciaSection of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore Rome, Italy.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

The aim of this study is to investigate the prognostic role of body mass index (BMI) on survival from head and neck cancer (HNC). We performed a pooled analysis of studies included in the International Head and Neck Cancer Epidemiology consortium. We used Cox proportional hazards models to estimate the adjusted hazard ratios (HR) for overall survival and HNC-specific survival, and we stratified the results according to cancer site. The study included 10,177 patients from 10 studies worldwide. Underweight patients had lower overall survival (HR=1.69, 95% CI: 1.31-2.19) respect to those having normal weight with consistent results across the HNC sites. Overweight and obese patients had a favourable HNC-specific survival (HR=0.77 (95% CI: 0.70-0.84) and HR=0.80 (95% CI: 0.76-0.84), respectively), with heterogenous results according to HNC site. Our findings show that high BMI values at cancer diagnosis improved the survival rates in patients with HNC, especially among smokers. This association may be explained by residual confounding, reverse causation, and collider stratification bias, but may also suggest that a nutritional reserve may help patients survive HNC cancer.

Indexed as

Body mass indexhead and neck cancersurvival

Identifiers

PMID39659941
PMCPMC11626270

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.