Evidence map›Paper›PMID 39659757›Full record

ArticleMolecular therapy. Methods & clinical development2024

Exogenous expression of ATP8, a mitochondrial encoded protein, from the nucleus

David V Begelman, Bhavna Dixit, Carly Truong, Christina D King, Mark A Watson, Birgit Schilling, Martin D Brand, Amutha Boominathan

Abstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. The first complete mitochondrial genome sequences ofFrontiers in veterinary science · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David V BegelmanSENS Research Foundation, Mountain View, CA 94041, USA.
Bhavna DixitSENS Research Foundation, Mountain View, CA 94041, USA.
Carly TruongSENS Research Foundation, Mountain View, CA 94041, USA.
Christina D KingBuck Institute for Research on Aging, Novato, CA 94945, USA.
Mark A WatsonBuck Institute for Research on Aging, Novato, CA 94945, USA.
Birgit SchillingBuck Institute for Research on Aging, Novato, CA 94945, USA.
Martin D BrandBuck Institute for Research on Aging, Novato, CA 94945, USA.
Amutha BoominathanSENS Research Foundation, Mountain View, CA 94041, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Replicative errors, inefficient repair, and proximity to sites of reactive oxygen species production make mitochondrial DNA (mtDNA) susceptible to damage with time. We explore

Indexed as

allotopic expressionATP8 genein vivo gene therapymitochondrial DNA mutationmtDNAsafe harbor expressiontransgenic mouse

Identifiers

PMID39659757
PMCPMC11629202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.