ArticleAesthetic surgery journal. Open forum2024
Short-Term Effects of Poly-L-Lactic Acid-b-Polyethylene Glycol Microsphere Injection on Different Adipose Tissue Types in Rats.
Article in Aesthetic surgery journal. Open forum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- PLLA Microspheres Regulate Adipocyte Dedifferentiation via Lactate: A Novel Strategy for Fat Graft Survival Enhancement.Aesthetic plastic surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Wrinkles and sagging, characteristics of aging, are associated with reductions in collagen and fat. Poly-L-lactic acid (PLLA) is widely used clinically as a tissue filler owing to its good biocompatibility and ability to improve wrinkles and signs of aging. Despite extensive studies of the mechanism of action of PLLA when used as a dermal filler, few studies have examined its effects on adipose tissue. Objectives: The short-term effects of PLLA-b-polyethylene glycol (PEG) microspheres implanted in subcutaneous back adipose tissue (BAT) and visceral epididymal adipose tissue (EAT) of rats were examined. Methods: The authors divided 15 male Sprague-Dawley rats into 5 groups based on implantation time, and PLLA-b-PEG microspheres were implanted into the BAT (3 groups were sampled at 6, 8, and 12 weeks) and EAT (2 groups were sampled at 6 and 12 weeks) of rats. Tissue samples were collected at different time points postimplantation and subjected to histological analyses using hematoxylin and eosin, Masson's trichrome, and immunofluorescence staining. Results: Implantation of PLLA-b-PEG microspheres into different adipose tissues resulted in a mild and persistent inflammatory reaction, increased fibrous connective tissue, and noticeable collagen regeneration. Immunofluorescence showed the upregulation of uncoupling protein (UCP) 1 and UCP2 in the visceral adipose tissue surrounding the implant. Conclusions: PLLA-b-PEG microspheres exhibited good tissue compatibility and induced an increase in fibrous connective tissue postimplantation, potentially mitigating oxidative damage and improving adipose tissue quality. Level of Evidence 5 Therapeutic:
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Registered trials
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