Evidence map›Paper›PMID 39659725›Full record

ArticleBioactive materials2025

Rapid assessment of the osteogenic capacity of hydroxyapatite/aragonite using a murine tibial periosteal ossification model.

Emma Steijvers, Yunshong Shi, Hong Lu, Weixin Zhang, Yitian Zhang, Feihu Zhao, Baichuan Wang, Louise Hughes, Jake E Barralet, Giulia Degli-Alessandrini and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Emma SteijversCentre for Nanohealth, Swansea University Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Swansea, United Kingdom.
Yunshong ShiCentre for Nanohealth, Swansea University Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Swansea, United Kingdom.
Hong LuCentre for Nanohealth, Swansea University Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Swansea, United Kingdom.
Weixin ZhangDepartment of Orthopaedics, Johns Hopkins Medical School, Baltimore, MD, 21205, United States.
Yitian ZhangFaculty of Science and Engineering, Swansea University, Swansea, United Kingdom.
Feihu ZhaoFaculty of Science and Engineering, Swansea University, Swansea, United Kingdom.
Baichuan WangCentre for Nanohealth, Swansea University Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Swansea, United Kingdom.
Louise HughesOxford Instruments NanoAnalysis, Halifax Road, High Wycombe, Bucks, HP12 3SE, United Kingdom.
Jake E BarraletFaculty of Dentistry and Health Sciences, Surgical and Interventional Sciences Division, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University, Quebec, Canada.
Giulia Degli-AlessandriniThe Open University, Electron Microscopy Suite, Walton Hall, Milton Keynes, MK7 6AA, United Kingdom.
Igor KraevThe Open University, Electron Microscopy Suite, Walton Hall, Milton Keynes, MK7 6AA, United Kingdom.
Richard JohnstonFaculty of Science and Engineering, Swansea University, Swansea, United Kingdom.
Zengwu ShaoDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frank H EbetinoDepartment of Chemistry, University of Rochester, Rochester, NY, 14627, United States.
James T TriffittNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom.
R Graham G RussellNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom.
Davide DeganelloFaculty of Science and Engineering, Swansea University, Swansea, United Kingdom.
Xu CaoDepartment of Orthopaedics, Johns Hopkins Medical School, Baltimore, MD, 21205, United States.
Zhidao XiaCentre for Nanohealth, Swansea University Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Swansea, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomaterials are widely used as orthopaedic implants and bone graft substitutes. We aimed to develop a rapid osteogenic assessment method using a murine tibial periosteal ossification model to evaluate the bone formation/remodelling potential of a biomaterial within 2-4 weeks. A novel hydroxyapatite/aragonite (HAA) biomaterial was implanted into C57BL/6 mice juxtaskeletally between the tibia and tibialis anterior muscle. Rapid intramembranous bone formation was observed at 14 days, with 4- to 8-fold increases in bone thickness and callus volume in comparison with sham-operated animals (

Indexed as

BiomaterialsHydroxyapatite/aragoniteIntramembranous ossificationOsteogenesis assessmentTibial periosteal bone formation

Identifiers

PMID39659725
PMCPMC11629149

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.