A case report of verapamil toxicity leading to haemodynamic compromise in obstructive hypertrophic cardiomyopathy.

Jonathan W Gau, Florian Rader, Behram Mody, Andy Y Lee

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In one paragraph

Article in European heart journal. Case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

4 authors.

Jonathan W GauDepartment of Internal Medicine, School of Medicine, University of California, Irvine, 101 City Dr S, Orange, CA 92868, USA.ORCID https://orcid.org/0009-0002-2297-4618

Florian RaderDepartment of Cardiology, Cedars-Sinai Medical Center, Smidt Heart Institute, 127 S San Vicente Blvd Pavilion Suite A3600, Los Angeles, CA 90048, USA.

Behram ModyDepartment of Medicine, Division of Cardiology, University of California, Irvine, 333 City Blvd W, Orange, CA 92868, USA.

Andy Y LeeDepartment of Medicine, Division of Cardiology, University of California, Irvine, 333 City Blvd W, Orange, CA 92868, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hypertrophic cardiomyopathy (HCM) is an inherited condition characterized by left ventricular (LV) hypertrophy unexplained by increased afterload, often with concomitant outflow tract obstruction. Verapamil is commonly used to treat symptomatic patients. However, its potential for adverse effects should be recognized. Case summary: This report provides a case of cardiogenic shock in HCM, where a patient presented with chief complaint of fatigue and shortness of breath with an acute decline in LV systolic function on echocardiogram. His symptoms were attributed to verapamil toxicity following a recent increase in dosage. He achieved rapid symptom relief after holding his home medications, in addition to conservative management. Discussion: This case report aims to elucidate the potential for multiple adverse effects involved with verapamil use in patients with obstructive HCM.

Indexed as

Case reportEchocardiogramObstructive hypertrophic cardiomyopathyVerapamil toxicity

Identifiers

PMID39659452

DOI10.1093/ehjcr/ytae596

PMCPMC11630018

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