ArticleCureus2024
Association Between Anxiety and Reflux Symptoms in Patients With Gastroesophageal Reflux Disease: A Prospective Cohort Study.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Mitral Valve Prolapse and Anxiety Disorders: A Systematic Review of Evidence in Both Directions and Meta-Analysis.Journal of clinical medicine · 2026Review
- Transformer-based InsightGWAS improves GERD genetic discovery via pretraining on GWAS for major depressive disorder.Communications biology · 2026Article
- Reflux esophagitis patients exhibit reduced gastric tolerance, impaired slow-wave activity and esophageal dysmotility.Frontiers in medicine · 2026Article
- Low pillow height is associated with LPR among patients with GERD: a retrospective single-center study.BMC gastroenterology · 2025Article
- Association of Constipation and Geriatric Depressive Symptoms: Cross-Sectional Analysis Using Baseline Data from the JUSTICE-TOKYO Prospective Cohort Study.Diagnostics (Basel, Switzerland) · 2025Article
- The relationship between anxiety symptoms and gastrointestinal symptoms in gastroenterology outpatients aged 6 to 18 years with the mediating role of sleep quality.Scientific reports · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
objectiveThe purpose of this paper is to examine the prevalence and symptom severity of anxiety and depression in patients with gastroesophageal reflux disease (GERD). The correlation between anxiety and depression with the DeMeester score is determined. GERD is a common gastrointestinal disorder that manifests as heartburn, regurgitation, retrosternal pain, cough, and dysphagia. Patients are severely affected by reflux symptoms.
methodsWe conducted a prospective cohort study of 458 consecutively enrolled patients who presented to the Department of Functional Upper GI Surgery at the University Hospital of Cologne, Germany. Patients underwent upper gastrointestinal endoscopy, 24-hour pH impedance testing, and high-resolution manometry. We determined the DeMeester score. Psychometric data were collected using the Hospital Anxiety and Depression Scale (HADS).
results44.1% (n = 202) of patients had abnormally high HADS anxiety scores and 23.8% (n = 109) had abnormally high HADS depression scores (both >7). Patients without an indication for surgery (51.1%, n = 234) were the most distressed subgroup: 47.9% (n= 112) of these patients had an anxiety score of 8 or higher, and as many as 23.9% (n = 56) of these patients had an anxiety score of 11 or higher. We found a significant effect of elevated anxiety and elevated depression scores on the severity of symptoms such as heartburn and fullness, as well as an effect of elevated anxiety scores on the severity of dysphagia.
conclusionPatients with reflux symptoms have a high prevalence of anxiety. Anxiety and partly depression are significantly associated with the severity of reflux symptoms. An adequate multidisciplinary treatment strategy is required.
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