ArticleStatistical methods in medical research2025
Youden index estimation based on group-tested data.
Article in Statistical methods in medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Discriminatory Capacity of Anthropometric Indicators and Physical Fitness Tests for Identifying Waist-to-Height Ratio-Defined Cardiometabolic Risk in Adolescents According to Sex and Biological Maturity.Children (Basel, Switzerland) · 2026Article
- Data-independent fluorescence molecular imaging analysis: a two-stage clustering framework for intraoperative tumor imaging.Biomedical engineering online · 2026Article
- Plasma haem oxygenase-1 and interleukin-6 as adjunct host biomarkers associated with malaria.Frontiers in immunology · 2026Article
- The role of the sulcus angle in patellar dislocation: The importance of measuring four magnetic resonance imaging axial levels and utilising corresponding cutoff values.Journal of experimental orthopaedics · 2025Article
- Clinical features of influenza-associated pulmonary aspergillosis: a retrospective multicenter cohort study.Frontiers in cellular and infection microbiology · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Youden index, a linear function of sensitivity and specificity, provides a direct measurement of the highest diagnostic accuracy achievable by a biomarker. It is maximized at the cut-off point that optimizes the biomarker's overall classification rate while assigning equal weight to sensitivity and specificity. In this paper, we consider the problem of estimating the Youden index when only group-tested data are available. The unavailability of individual disease statuses poses a challenge, especially when there is differential false positives and negatives in disease screening. We propose both parametric and nonparametric procedures for estimation of the Youden index, and exemplify our methods by utilizing data from the National Health and Nutrition Examination Survey (NHANES) to evaluate the diagnostic ability of monocyte for predicting chlamydia.
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