ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Genomic Epidemiology of Pseudomonas aeruginosa Sequence Type 111.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Detection of the ST111 Global High-RiskCurrent issues in molecular biology · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
purposePseudomonas aeruginosa ST111 is a global multidrug resistant (MDR) high-risk clone and comprehensive data about its molecular epidemiology is limited in Canada. Comprehensive data about the evolution of ST111 clades is limited. We characterized a Canadian collection of ST111 causing bloodstream infections and investigated the genomic relationship between Canadian and global ST111. MATERIAL AND
methodsWe used long and short read WGS to characterize Canadian ST111 (n = 10 from 2010-18). We performed phylogenetic analysis on a global collection of ST111 (n = 969) and investigated the evolutionary history of clades using BEAST.
resultsST111 belonged to 3 clades (A, B, C) and two subclades (C1, C2). ST111-A was the ancestral clade while clades B, C1 and C2 emerged during the 1700s and 1800s. ST111-C2 dominated the global ST111 population. Serotype switching from O4 to O12 and the acquisition of Tn21, gyrA_T83I, parC_S87L, In59 with bla
conclusionsWe provided details on the emergence and evolution of different ST111 clades over time and highlighted the roles of serotype switching and the acquisition of certain AMR determinants and transposon structures in the evolution of ST111-C2.
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