Evidence map›Paper›PMID 39658693›Full record

ReviewClinical oral investigations2024

Main genetic entities associated with tooth agenesis.

Francisco Cammarata-Scalisi, Colin E Willoughby, Jinia R El-Feghaly, Antonio Cárdenas Tadich, Maykol Araya Castillo, Shadi Alkhatib, Marwa Abd Elsalam Elsherif, Rabab K El-Ghandour, Riccardo Coletta, Antonino Morabito and 1 more

Abstract readReview
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In one paragraph

Review in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Dissecting the Genetic Contribution of Tooth Agenesis.International journal of molecular sciences · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Francisco Cammarata-ScalisiPediatric Service, Regional of Antofagasta Hospital, Antofagasta, Chile. francocammarata19@gmail.com.
Colin E WilloughbyGenomic Medicine, Biomedical Sciences Research Institute, Ulster University, Coleraine, Northern Ireland.
Jinia R El-FeghalyDepartment of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.
Antonio Cárdenas TadichPediatric Service, Regional of Antofagasta Hospital, Antofagasta, Chile.
Maykol Araya CastilloClinical Laboratory, Regional of Antofagasta Hospital, Antofagasta, Chile.
Shadi AlkhatibPediatric Dentistry, Dubai, UAE.
Marwa Abd Elsalam ElsherifPediatric Dentistry, Nile of Hope Hospital, Alexandria, Egypt.
Rabab K El-GhandourPharos University, Alexandria, Egypt.
Riccardo ColettaSchool of Health and Society, University of Salford, Salford, UK.
Antonino MorabitoSchool of Health and Society, University of Salford, Salford, UK.
Michele CalleaPostgraduate in Oral Surgery, University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTooth agenesis refers to the absence of one or more of the deciduous or permanent teeth. Tooth agenesis results from a series of disrupted reciprocal ectodermal mesenchymal interactions taking place during the early stages of tooth development.

methodsA narrative literature review was performed to describe the main genetic syndromes associated with tooth agenesis. RESULTS AND

conclusionsThe etiology of congenital tooth agenesis is multifactorial and include genetic, epigenetic, and environmental influences. Syndromes associated with chromosomal alterations, ectodermal dysplasia, Axenfeld-Rieger syndrome, oral-facial cleft syndromes, and syndromes with cancer predisposition are among the main entities presenting with tooth agenesis. CLINICAL RELEVANCE: Tooth agenesis disorders can affect the masticatory function and cause disfigurement leading to physiological and psychological complications. Early recognition of these entities is crucial to guide the management of the patient and to provide families with the appropriate genetic counseling.

Indexed as

AnodontiaEctodermal DysplasiaHumansChromosomal alterationsEctodermal dysplasiaEtiologyOral-facial cleft syndromeTooth agenesis

Identifiers

PMID39658693

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.