Detoxification of hydrogen sulfide by synthetic heme model compounds.

Atsuki Nakagami, Qiyue Mao, Masaki Horitani, Masahito Kodera, Hiroaki Kitagishi

Abstract read

In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Atsuki NakagamiDepartment of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe-city, Kyoto, 610-0321, Japan.

Qiyue MaoDepartment of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe-city, Kyoto, 610-0321, Japan.

Masaki HoritaniDepartment of Applied Biochemistry and Food Science, Faculty of Agriculture, Saga University, 1 Honjo-machi, Saga, 840-8502, Japan.

Masahito KoderaDepartment of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe-city, Kyoto, 610-0321, Japan.

Hiroaki KitagishiDepartment of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe-city, Kyoto, 610-0321, Japan. hkitagis@mail.doshisha.ac.jp.

Funding

Japan Agency for Medical Research and Development 23ym0126814Japan Science and Technology Corporation JPMJSF2305Japan Science and Technology Corporation JPMJSP2129Japan Society for the Promotion of Science 22H02097Ministry of Education, Culture, Sports, Science and Technology JPMXP1224MS1025

6 · The paper itself

Abstract

Hydrogen sulfide is a lethal toxic gas that disrupts cellular respiration in the mitochondrial system. Currently, no antidote is available for the clinical treatment of hydrogen sulfide poisoning. In this study, we investigated the function of iron(III)porphyrin complexes as hydrogen sulfide scavengers in water and evaluated their potential use as therapeutic agents for hydrogen sulfide poisoning. The compounds, named met-hemoCD-P and met-hemoCD-I, are composed of iron(III)porphyrin complexed with per-methylated β-cyclodextrin dimers that contain a pyridine (met-hemoCD-P) or imidazole axial fifth ligand that is coordinated to Fe(III) (met-hemoCD-I). These compounds formed stable HS-Fe(III) complexes under physiological conditions, with binding constants of 1.2 × 10

Indexed as

HemeHydrogen SulfideAnimalsElectron Spin Resonance SpectroscopyHumansInactivation, MetabolicMaleMiceHemeHydrogen SulfideCyclodextrinHemeHydrogen sulfideInjectable antidotePorphyrin

Identifiers

PMID39658563

DOI10.1038/s41598-024-80511-1

PMCPMC11632086

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.