ArticleEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2024
Feasibility and accuracy of DireCt Lung Ultrasound Evaluation technique to monitor extravascular lung water in porcine lungs.
Article in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Micro/nanoscale bubble-mediated mucolytic conditioning of the lung model of cystic fibrosis enhances nanoparticle transport through the mucus.Biomaterials · 2026Article
- Time as a Therapeutic Ally: The Promise of Long-Term Solid Organ and Tissue Perfusion.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
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Abstract
objectivesExtravascular lung water precedes deterioration of pulmonary function. Current tools to assess extravascular lung water in a setting of donor lung procurement and ex vivo lung perfusion (EVLP) are either subjective or not feasible. Therefore, a direCt Lung Ultrasound Evaluation (CLUE) has been introduced. This study reassesses the feasibility and accuracy of CLUE by measuring its correlation with lung weight, wet-to-dry ratio (W/D ratio), dynamic compliance and pulmonary vascular resistance (PVR) in a porcine model.
methodsCLUE images, lung weight, dynamic compliance and PVR were recorded and lung samples for W/D ratio were taken before and after EVLP. CLUE score was calculated based on B-lines on images taken at each point of the lung using an established equation.
resultsEighteen porcine lungs were included. Total median of CLUE score, lung weight, W/D ratio and PVR increased significantly, while median of dynamic compliance decreased significantly after EVLP. Total median CLUE score increased significantly in all four surfaces after EVLP with equally high CLUE scores in posterior and diaphragm lines. CLUE score demonstrated a significant strong positive correlation with lung weight (r = 0.825) and W/D ratio (r = 0.837), while CLUE's correlation with dynamic compliance and PVR was significantly moderate to strong (r = -0.669, r = 0.695, respectively).
conclusionsCLUE technique is feasible to assess extravascular lung water in donor lungs after procurement and during EVLP. CLUE score correlated significantly with lung weight, W/D ratio, dynamic compliance and PVR. Transplant suitability of a donor lung may not solely depend on CLUE evaluation.
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