Evidence map›Paper›PMID 39657997›Full record

ArticleACS infectious diseases2025

Drug Interaction Studies of Cabamiquine:Ganaplacide Combination against Hepatic

Isabella Ramella Gal, Claudia Demarta-Gatsi, Diana Fontinha, Francisca Arez, Sebastian G Wicha, Matthias Rottmann, Helena Nunes-Cabaço, Johanne Blais, Jay Prakash Jain, Suresh B Lakshminarayana and 4 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Isabella Ramella GaliBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901 Oeiras, Portugal.
Claudia Demarta-GatsiGlobal Health R&D of the healthcare business of Merck KGaA, Darmstadt, Germany, Ares Trading S.A., (an affiliate of Merck KGaA, Darmstadt, Germany, Route de Crassier 1, 1262 Eysins, Switzerland.
Diana FontinhaInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.ORCID 0000-0002-0046-648X
Francisca AreziBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901 Oeiras, Portugal.
Sebastian G WichaDepartment of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany.
Matthias RottmannSwiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland.
Helena Nunes-CabaçoInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.
Johanne BlaisGlobal Health, BioMedical Research at Novartis, Emeryville, California 94608-2916, United States.
Jay Prakash JainGlobal Health, BioMedical Research at Novartis, Emeryville, California 94608-2916, United States.
Suresh B LakshminarayanaGlobal Health, BioMedical Research at Novartis, Emeryville, California 94608-2916, United States.
Catarina BritoiBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901 Oeiras, Portugal.
Miguel PrudêncioInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.ORCID 0000-0003-1746-6029
Paula M AlvesiBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901 Oeiras, Portugal.
Thomas SpangenbergGlobal Health R&D of the healthcare business of Merck KGaA, Darmstadt, Germany, Ares Trading S.A., (an affiliate of Merck KGaA, Darmstadt, Germany, Route de Crassier 1, 1262 Eysins, Switzerland.ORCID 0000-0002-5654-8919

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New antimalarial combination therapies with novel modes of action are required to counter the emergence and spread of

Indexed as

AntimalarialsMalariaPlasmodium bergheiAnimalsCell LineDrug InteractionsDrug Therapy, CombinationHepatocytesHumansLiverMiceQuinolinesAntimalarialsQuinolinesAntimalarialCabamiquineCombination therapyGanaplacideLiver stage infectionPreclinical

Identifiers

PMID39657997
PMCPMC11731318

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.