Evidence map›Paper›PMID 39657993›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Impaired maternal central hemodynamics precede the onset of vascular disorders of pregnancy at high altitude.

Rosalieke E Wiegel, Kori Baker, Carla Calderon-Toledo, Richard Gomez, Sergio Gutiérrez-Cortez, Julie A Houck, Alison Larrea, Litzi Lazo-Vega, Lorna G Moore, Julia Pisc and 2 more

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Beyond blood flow: the multifaceted role of AMPK in regulating fetal growth at high altitudes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rosalieke E WiegelDepartment of Obstetrics and Gynecology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Kori BakerDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-2264-3088
Carla Calderon-ToledoInstituto de Biología Molecular y Biotecnología, Department of Biology, Universidad Mayor de San Andrés, La Paz, Bolivia.ORCID 0000-0001-9483-9891
Richard GomezDepartment of Obstetrics, Hospital Materno-Infantil, La Paz, Bolivia.
Sergio Gutiérrez-CortezInstituto de Biología Molecular y Biotecnología, Department of Biology, Universidad Mayor de San Andrés, La Paz, Bolivia.ORCID 0000-0001-6181-6554
Julie A HouckDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Alison LarreaDepartment of Obstetrics, Hospital Materno-Infantil, La Paz, Bolivia.
Litzi Lazo-VegaDepartment of Obstetrics, Hospital Materno-Infantil, La Paz, Bolivia.ORCID 0000-0001-9594-7384
Lorna G MooreDepartment of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0001-5637-0025
Julia PiscSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Lilian Toledo-JaldinDepartment of Obstetrics, Hospital Materno-Infantil, La Paz, Bolivia.
Colleen G JulianDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0001-8857-0152

Funding

Effects of chronic hypoxia and AMPK activation on uteroplacental perfusion, placental metabolism and the regulation of fetal growthR01HD088590 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Colleen Glyde Julian, LORNA G. MOORE · 2016 to 2026
$4.3M
Epigenetic and Fetal Origins of Hypoxia-Induced Pulmonary HypertensionR01HL138181 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI JULIAN, COLLEEN GLYDE · 2018 to 2021
$1.6M
Novel NF-kB variant in preeclampsiaR21HD111905 · NICHD · UNIVERSITY OF COLORADO DENVER · PI JULIAN, COLLEEN GLYDE · 2024 to 2025
$429k
Novel roles of purinergic signaling for altitude-associated fetal growth restrictionR21HD111908 · NICHD · UNIVERSITY OF COLORADO DENVER · PI JULIAN, COLLEEN GLYDE, LORCA, RAMON A · 2024 to 2025
$429k
Antenatal Exposures and Non-Communicable Disease(ANDES): Building research capacity to identify and treat causes of NCD in BoliviaR21TW010797 · FIC · UNIVERSITY OF COLORADO DENVER · PI JULIAN, COLLEEN GLYDE, MOORE, LORNA G. · 2017 to 2018
$389k
FIC NIH HHS R21 TW010797NHLBI NIH HHS R01 HL138181NICHD NIH HHS R01 HD088590NICHD NIH HHS R21 HD111905NICHD NIH HHS R21 HD111908University of Colorado (CU) Anschutz Medical Campus (Division of Reproductive Sciences in the Department of Obstetrics and Gynecology)University of Colorado (CU) Department of Medicine Research and Equity in Academic Medicine (DREAM) Program
6 · The paper itself

Abstract

Hypertensive disorders of pregnancy represent an escalating global health concern with increasing incidence in low- to middle-income countries and high-income countries alike. The current lack of methods to detect the subclinical stages of preeclampsia (PE) and fetal growth restriction (FGR), two common vascular disorders of pregnancy, limits treatment options to minimize acute- and long-term adverse outcomes for both mother and child. To determine whether impaired maternal cardiovascular or uteroplacental vascular function precedes the onset of PE and/or FGR (PE-FGR), we used noninvasive techniques to obtain serial measurements of maternal cardiac output (CO), stroke volume (SV), systemic vascular resistance (SVR), and uterine and fetal arterial resistance at

Indexed as

AltitudeFetal Growth RetardationHemodynamicsPre-EclampsiaAdultBoliviaCase-Control StudiesFemaleGestational AgeHumansInfant, NewbornPlacental CirculationPregnancyUterine ArteryVascular ResistanceYoung Adultcardiac outputmaternal hemodynamicspreeclampsiasystemic vascular resistanceuteroplacental blood flow

Identifiers

PMID39657993
PMCPMC11901344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.